干燥综合征

Overview of Sjogren's Syndrome

干燥综合征是一种常 见的慢性炎症性自身免疫病,其病因与发病机制至今尚不清楚。除侵犯唾液腺、泪腺等外分泌腺体而出现相应的症状外,肺、肾、胃肠道、血液系统等多器官、多系统均可受累。目前国际上尚无统一的干燥综合征诊断标准。干燥综合征起病隐匿、病情进展相对缓慢。病变仅局限于外分泌腺者预后良好,予对症治疗即可;而出现肺间质纤维化、肾小球损害、中枢神经系统病变以及演变为恶性淋巴瘤者预后差,需要积极的激素及免疫抑制剂治疗。

Sjogren's syndrome is one of the most common autoimmune dis-eases. It has been reported that heredity, in-fection and immune disturbance are all in- volved in the etioiogy and pathogenesis al-though they are stili unclear. Besides the ex-ocrine glands such as salivary gland and lacrimal gland, lung, kidney, gastrointestinal, hemolytic system can also be involved. There is no consented diagnostic criteria at present Sjogren' s syndrome is a comparatively benign autoimmune systemic disease except for the patients with pulmonary interstitial fibrosis, glomerular involvement, injury of central ner-vous system and malignant lymphoma. Steroid and immunosuppressive agents should be given to these patients with possibly poor prognosis while symptom-relieving therapy is enough for those patients whose exocrine gland is the only involved organ.