不同方法留取系统性红斑狼疮病人尿标本中微量蛋白含量观察

Observation on Different Ways of Collecting Urine Samples for Detecting Micro-protein in SLE

为了正确选择系统性红斑狼疮 (SLE)病人尿微量转铁蛋白 (Tf)、白蛋白(UMA )和免疫球蛋白G标本留取方法 ,收集 2 2例尿常规检查尿蛋白阴性的SLE病人晨尿、随机尿和 2 4h尿标本 ,采用速率散射比浊法测定Tf、UMA和IgG。结果 :晨尿与 2 4h尿标本中Tf、UMA和IgG检出率无显著性差异 (P >0 .0 5 ) ,随机尿与 2 4h尿标本中Tf、UMA和IgG检出率有统计学差异 (P <0 .0 5 )。提示 :晨尿与 2 4h尿微量蛋白含量均可作为反映肾损害的敏感指标 ,而晨尿留取方法简便易行。

To select the correct way of collecting urine samples for determination of microtransferrin (Tf),microalbumin (UMA) and immunoglobulin G (IgG), 22 cases of urina protein-negative SLE patients were asked to collect their urina sanguinis and randomly passed urine. Tf, UMA and IgG were detected in all the urine samples by rate nephelometry. Results showed that there was no significant difference between the urina sanguinis and randomly passed urine in terms of Tf, UMA and IgG detectable rate (P>0.05). There was significant difference between randomly collected urine sample and 24h collected urine sample in terms of Tf, UMA and IgG detectable rate (P<0.05). Suggested that urine microprotein content in both urina sanguinis and 24h collected urine be as sensitive norms to reflect renal damages. And urina sanguinis collection is more simple and easy to carry out.