肠道与微生物相互作用体外研究模型进展与应用

Advances and Applications of in Vitro Models for Host-Microbe Interactions Research

肠道微生物对机体的营养代谢、能量代谢和免疫功能等具有十分重要的作用,而微生物黏附、定植以及同宿主肠上皮的相互作用在这些过程中至关重要,因而深入理解微生物和肠道之间的相互作用是阐明微生物如何参与机体营养、代谢和免疫过程的关键。本文综述了研究微生物与肠道相互作用的主要体外模型,以及应用这些模型取得的研究进展。

Gut microbes play important roles in the nutrient metabolism, energy metabolism and immune func- tion. Microbial adhesion, colonization, and interactions with host intestinal epithelial ceils in these processes are essential, therefore in-depth understanding of crosstalk between the microbe and the host is a key to clarify how microbes involve in nutritional, metabolic and immune processes. In this paper, we reviewed several in- testinal microbe interaction research models, as well as the advances and applications in these models. ~ Chinese Journal of Animal Nutrition, 2013, 25 （ 8 ） ： 1677-16821