缺血性脑卒中患者幽门螺杆菌感染与超敏C反应蛋白相关性研究

Study on correlation between Helicobacter pylori infectis and high sensitive C reactive protein in patients with ischemic stroke

目的观察缺血性脑卒中患者感染幽门螺杆菌的情况,并研究其与超敏C反应蛋白的相关性,为缺血性脑卒中患者幽门螺杆菌感染的诊治提供试验依据。方法选取神经内科收治的缺血性脑卒中急性期的患者70例为脑卒中组,选取同期健康体检者70名为对照组,比较两组患者幽门螺杆菌感染以及超敏C反应蛋白水平。结果脑卒中组患者的检测阳性率为65.71%,明显高于对照组的38.57%,差异有统计学意义(P<0.05);脑卒中组患者中,感染幽门螺杆菌的超敏C反应蛋白水平为(7.91±4.19)mmol/L,明显高于未感染幽门螺杆菌的患者的(5.38±4.27)mmol/L,差异有统计学意义(P<0.05)。结论幽门螺杆菌的感染与超敏C反应蛋白升高和动脉粥样硬化发生密切相关,两者可能是缺血性脑卒中发生的危险因素之一。

OBJECTIVE To observe the incidence of Helicobacter pylori infections in the patients with ischemic stroke and to investigate the correlation between the H. pylori infections and high sensitive C reactive protein so as to provide solid basis for the diagnosis and treatment of this disease. METHODS A total of 70 patients with acute cerebral stroke were selected from the neurology department and were set as the stroke group, while the same number of people who underwent the medical examination without significant disease were set as the control group. The H. pylori infections and the concentration of high sensitivity C reactive protein were compared be- tween the two groups. RESULTS The positive rate of stroke in the stroke group was 65.71%, significantly higher than 38.57% of the control group, the difference was statistically significant （P〈0.05）. In the stroke group, the hypersensitivity C reactive protein level of the patients with H. pylori infections was （7.91 ± 4. 19） retool/L, significantly higher than （5.38 ±4.27） mmol/L of the patients without H. pylori infections, the difference was statistically significant （P〈0.05）. CONCLUSION The H. pylori infection is closely related to the elevated level of high sensitive C reactive protein and the occurrence of atherosclerosis, which may he one of the main risk factors of the ischemic stroke.