抗菌药物专项整治后门诊抗菌药物使用分析

Antibiotics usage in outpatient department after new antibiotic policy

目的了解抗菌药物专项整治后医院门诊抗菌药物使用情况,为继续深入开展抗菌药物临床应用整治工作提供数据。方法随机抽取2011年9月-2012年2月的门诊处方5500张,统计抗菌药物使用情况,并评价抗菌药物使用的合理性。结果使用抗菌药物处方共821张,占统计处方的14.9%,共涉及抗菌药物11类48个品种;联合使用抗菌药物处方131张,占总抗菌药物处方的15.96%,其中,二联抗菌药物处方129张、三联抗菌药物处方2张,分别占抗菌药物联合用药处方的98.47%和1.53%,无>三联联合用药;用药频率较高前3类抗菌药物为大环内酯类、头孢菌素类和氟喹诺酮类,分别占总抗菌药物使用频率的33.66%、33.02%和10.17%;药物利用指数(DUI)>1.0的抗菌药物类别为大环内酯类和四环素类;使用频率较高前3位的抗菌药物为克拉霉素片、头孢克洛胶囊和头孢呋辛酯片;DUI>1.0的抗菌药物为多西环素片、克拉霉素片、阿莫西林胶囊和左氧氟沙星片。结论抗菌药物专项整治后医院门诊抗菌药物使用基本合理,但仍存在一些问题有待改进。

OBJECTIVE To investigate the antibiotic usage in the outpatient department after new antibiotic policy so as to provide data for further management work on clinical application of antibiotics. METHODS A total of 5500 prescriptions for outpatients from Sap 2011 to Feb 2012 were randomly collected. Then the utilization of antibacte- rials was calculated and analyzed, and the rationality of the use of antibiotics was evaluated. RESULTS The amount of antibiotic prescription was 821, accounting for 14. 9~~ of the total statistical prescriptions; 11 cate- gories and 48 species of antibiotics were used. The amount of combination antibiotic prescription was 131, accoun- ted for 15.96% of all antibiotic prescriptions; among them, two and three antibiotics combination was 129 and 2 prescriptions, respectively accounting for 98.47% and 1.53% of total combination antibiotic prescriptions; more than three antibiotics combination was not used. The top three sorts of DDDs were macrolides （33.66 % ）, cepha- losporins （33.02 % ） and fluoroquinolones （10.17% ） ; DUI of maerolides and tetracyclines was more than 1.0. The top three species of DDDs were the clarithromycin tablets, cefaclor capsules and cefuroxime axetil tablets;DUI of doxycycline tablets, elarithromycin tablets, amoxieillin capsules or levofloxacin tablets was more than 1. 0. CONCLUSION The antibiotics are rationally used in the outpatients after the new policy, however there are still some problems that need to be improved.