DNA股间交联及与细胞癌变关系的研究进展

DNA Interstrand Cross-linking and its Relationship with Carcinogenesis

癌症是目前全球共同面临的重大公共卫生问题。流行病学研究显示,大约80%～90%的人类癌症是由环境因素诱导产生的,其中又以化学因素占主导地位。化学致癌机理的双区理论认为,环境致癌物经体内代谢生成特定的双官能团烷化剂,从而诱导DNA双链互补碱基对之间的交联并最终引发癌症。目前针对DNA股间交联的检测方法已有不少研究,然而DNA股间交联如何引起细胞癌变的机理仍悬而未决,这也成为人们关注的焦点。本文旨在通过综述近年来对DNA股间交联的研究,从其结构、体内形成过程和检测方法等方面,探讨DNA股间交联与细胞癌变的关系,为环境致癌机理的研究提供思路。

All over the world, cancer has become a major public health problem. Epidemiological studies have shown that about 80% ~ 90% of human cancers are caused by the environment; the most important cancer-causing factors are chemical factors. Di-region theory, one mechanism of chemical carcinogens, pointed out that environmental carcinogenic agents were metabolized into a specific bi-functional alkylation agent, then induced DNA interstrand cross-linking and final caused cancer. Although there are many methods to detect DNA interstrand cross- linking, its mechanism that causes normal cells to become tumor is still unelearly, and has also become the focus of attention. Based on the structure, formation process and detection methods of DNA interstrand cross-linking, the research progress on the relationship of DNA interstrand cross-linking and cancer was reviewed in this paper. It hopes to provide some ideas for the research on the mechanism of environmental carcinogens.