阻塞性睡眠呼吸暂停低通气综合征患者血栓调节蛋白、血管性血友病因子水平的研究

Study on plasma TM,vWF levels in patients with obstructive sleep apneahypopnea syndrome

目的探讨阻塞性睡眠呼吸暂停低通气综合征(OSAHS)患者血浆血栓调节蛋白(TM)、血管性血友病因子(vWF)水平的变化及临床意义。方法选择OSAHS患者40例,健康对照者40例,采用酶联免疫吸附法测定受试者血浆TM、vWF水平。结果 OSAHS患者与对照组相比,血浆TM(451.19±48.41)v(s301.40±31.15)明显升高(P<0.05)、血浆vWF(631.40±21.76)v(s430.00±21.05)明显升高(P<0.05)。结论 OSAHS患者血浆TM、vWF水平明显升高,提示OSAHS患者存在血管内皮细胞功能受损及抗凝作用的减弱。

[ Objective ] To investigate the levels of plasma thrombomoduline （TM） and yon Willebrand Factor （vWF） in patients with obstructive sleep apneahypopnea syndrome （OSAHS） and their clinical signifieience. [ Meth- ods ] 40 OSAHS patients and 40 men in normal control subjects were selected. ELISA method was used to assay the levels of TM and vWF in Plasma. [ Results ] the level of TM in Plasma of patients with OSAHS was significantly higher than that of normal control subjects（P 〈0.05）. The level of vWF in Plasma of patients with OSAHS was signif- icantly higher than that of normal control subjects （P 〈0.05）. [ Conclusions ] The levels of TM and vWF in plasma of patients with OSAHS were significantly higher than those of normal control subjects. These results suggest that vas- cular endothelial cell function is damaged and anticoagulant function decreased in patients with OSAHS.