灵芝多糖抗肿瘤机制研究进展

Research Progress of the Ganoderan Antitumor Mechanism

目的综述灵芝多糖抗肿瘤机制研究进展。方法在总结国内外文献基础上,对灵芝多糖不同种类抗肿瘤作用机制进行综合与归纳。结果与结论目前多糖类药物作为抗肿瘤免疫调节剂成为一大研究热点,笔者主要从其提高宿主免疫功能、抑制肿瘤细胞增殖、抑制肿瘤转移、抗氧化、清除氧自由基、提高肿瘤细胞MHC及共刺激分子表达、诱导肿瘤细胞分化等作用进行综述。并对灵芝多糖研究目前存在的问题进行评述。

OBJECTIVE To review mechanism research progress of ganoderan antitumor. METHODS At the foundation of research literature of domestic and abroad, the different kinds of antitumor mechanism of ganoderan were summaried. RESULTS AND CONCLUSION Now, polysaecharides become a research hotspot as antitumor immunomodulator. The study reviewed mechanism of ganoderan antitumor at different fields ： elevating the immune function of host, inhibiting tumor cell proliferation and metastasis, anti-oxidant, clearing oxygen radicals,increasing the expression of tumor MHC and costimulatory molecules, inducing tumor cell differentiation. The study also observed the existent problem of ganoderan research.