摘要
目的综述灵芝多糖抗肿瘤机制研究进展。方法在总结国内外文献基础上,对灵芝多糖不同种类抗肿瘤作用机制进行综合与归纳。结果与结论目前多糖类药物作为抗肿瘤免疫调节剂成为一大研究热点,笔者主要从其提高宿主免疫功能、抑制肿瘤细胞增殖、抑制肿瘤转移、抗氧化、清除氧自由基、提高肿瘤细胞MHC及共刺激分子表达、诱导肿瘤细胞分化等作用进行综述。并对灵芝多糖研究目前存在的问题进行评述。
OBJECTIVE To review mechanism research progress of ganoderan antitumor. METHODS At the foundation of research literature of domestic and abroad, the different kinds of antitumor mechanism of ganoderan were summaried. RESULTS AND CONCLUSION Now, polysaecharides become a research hotspot as antitumor immunomodulator. The study reviewed mechanism of ganoderan antitumor at different fields : elevating the immune function of host, inhibiting tumor cell proliferation and metastasis, anti-oxidant, clearing oxygen radicals,increasing the expression of tumor MHC and costimulatory molecules, inducing tumor cell differentiation. The study also observed the existent problem of ganoderan research.
出处
《中国药学杂志》
CAS
CSCD
北大核心
2013年第16期1329-1332,共4页
Chinese Pharmaceutical Journal
基金
国家自然科学基金资助项目(81173177)
河南省教育厅自然科学研究计划资助项目(2010B360015)
郑州市科技创新团队资助项目(121PCXTD520)
河南中医学院2010博士基金项目(BSJJ2010-10)
关键词
灵芝多糖
肿瘤
机制
ganoderan
tumor
mechanism