头孢菌素C过滤过程中总过滤时间的优化与控制

Estimation and control of process time for membrane separation of cephalosporin C from fermentation broth

针对头孢菌素C(CPC)发酵液在工业生产中难过滤的问题,在收率衡算模型基础上,结合浓差极化机理引入时间参数,针对连续洗滤过程(CFD)建立考虑时间的膜分离过程估算式,并以最短膜处理时间tmin为目标进行了优化求解。结果表明,在优化的膜处理过程中,CPC收率从85%增长到95%所用时间占总处理时间的30%～40%;而前浓缩比a值在0.5～0.8范围内时,总膜过滤时间差别不大。在一个相对较宽的可操作范围内,适当调整前浓缩比或/和调整目标收率,可以对生产过程的时效性及CPC收率、滤液/保留液体积等生产指标进行优化与控制。

Cephalosporin C（CPC）fermentation broth is a typical material with high solid content and high viscosity.Under the condition of constant yield of CPC in filtrate,how to minimize the process time of membrane filtration is an interesting area in industrial applications.Based on the stagnant film theory and mass balance,the estimate equation is founded and the conditions to reach the minimum process time tmin are put forward.The results show that the time consumed is 30%—40% of the total process time when the yield of CPC is from 85% to 95%.Under the experiment conditions（pre-concentration ratio 0.5—0.8,post-concentration ratio 1）,the total filtration time is nearly the same.Based on the theoretical and experimental results,the production requirements as CPC yield,the volume of filtrate or retentate and the process effectiveness can be optimized and controlled properly.