5-羟色胺转运体基因多态性与抑郁的关系研究进展

Research Progress of Relationship Between Serotonin Transporter Gene Promoter Region Polymorphism and Depression

抑郁症作为一种复杂的情感性精神障碍,其病因及病理机制至今尚未完全阐明。5-羟色胺(5-HT)系统可能在抑郁的起病及发展中起重要作用,许多研究者在探索5-羟色胺转运体基因启动子区域连锁多态性(5-HTTLPR)与抑郁的关系上作了大量工作,已有许多研究成果出现,本文对以往的相关研究做一个综述。

Depression is a complex mental disorder, and its pathological mechanism has not yet been elucidated. The serotonin （5-H＇Iq） system may play an important role in the onset and course of depression. Many researchers have made a lot of studies on the relationship between serotonin transporter gene promoter region polymorphism （5-HTTLPR） and de- pression, and have reported many research findings. Here is to make a review about the past related studies.