黄芪对兔心肌梗塞后心肌血管紧张素和羟脯氨酸含量的影响

EFFECTS OF RADIX ASTRAGALI ON MYOCARDIAL ANGIOTENSIN Ⅱ AND HYDROXYPROLINE AFTER MYOCARDIAL INFARCTION

目的探讨急性心肌梗塞后心肌局部血管紧张素Ⅱ和羟脯氨酸含量的变化 ,观察黄芪的治疗作用。方法采用兔制备心肌梗塞模型 ,黄芪组自术后第 2d腹腔注射黄芪液 2～ 3ml,2次 /d ,共 3周。于术后第 6周处死动物 ,采集标本 ,检测梗塞区、游离壁及正常兔心肌血管紧张素Ⅱ和羟脯氨酸含量。结果心肌梗塞后心肌局部血管紧张素Ⅱ含量显著增加 (P <0 .0 1) ,梗塞区羟脯氨酸含量显著增加 (P <0 .0 1) ,游离壁羟脯氨酸含量略有增加(P >0 .0 5 ) ;经黄芪治疗后心肌血管紧张素Ⅱ含量明显下降 (P <0 .0 1) ,梗塞区羟脯氨酸含量略有下降 (P >0 .0 5 )。结论血管紧张素Ⅱ和羟脯氨酸参与左室重构 ,黄芪有一定的治疗作用。

ObjectiveTo study the changes of angiotensinⅡ(AngⅡ) and hydroxyproline(HP) in local myocardium after myocardial infarction, and observe the therapeutic effects of radix astragali.MethodsIn the radix astragali treated group radix astragali was injected ip, 2～3 ml, twice daily for three weeks. Finally 13 rabbits in radix astragali treated group and 12 in the control survived. All animals were killed in the sixth week after coronary ligation. AngⅡ and HP in the local myocardium were measured.ResultsAngⅡ in non infarcted zone and HP in infarcted zone were markedly increased after myocardial infarction(P< 0.01 ). In the radix astragali treated group AngⅡ was markedly decreased, and HP in the infarcted zone was also decreased, but the difference was not significant.ConclusionAngⅡ and HP were important factors in the left ventricular remodeling after myocardial infarction, and radix astragali had some therapeutic effects.