影响平阳霉素对口腔鳞癌化疗疗效的相关临床和病理因素分析

Analysis of clinical and pathological factors for tumor response to pingyangmycin chemotherapy in patients with oral squamous cell carcinoma

目的 :分析影响平阳霉素对口腔鳞癌化疗疗效的相关临床和病理因素 ,指导临床合理用药。方法 :从我院近 16年来接受平阳霉素化疗的病例中 ,筛选出接受平阳霉素治疗前未接受过化疗或放疗的病例共73例 ,按 WHO化疗疗效标准 ,分为有效组 (38例 )与无效组 (35例 ) ,对两组患者的年龄、性别、体重、肿瘤的生长部位、病理分级、生长方式、临床分期、平阳霉素的总剂量和给药方式等进行统计分析。结果 :1两组患者的年龄、性别、体重、肿瘤的病理 级 级、生长部位、临床分期、平阳霉素的总剂量和给药方式无显著性差异 (P>0 .0 5 ) ;2两组病变的生长方式对化疗疗效具有显著性差异 (P<0 .0 5 )。结论

objective: To assess the clinical and pathological factors for tumor response to pingyangmycin chemotherapy in patients with oral squamous cell carcinoma. Methods: 73 cases of oral squamous cell carcinoma, previously untreated,received preoperative chemotherapy of pingyangmycin were analysed statistically according to the various clinical and pathological factors.Results: 38 out of the 73 cases responsed (R) to the therapy,while 35 did not(N).There was no difference between the R and N cases according to the sex, age,body weight, pathologic grade Ⅰ and Ⅱ, primary site,clinical stage of tumor, and the total dose of pingyangmycin( P >0.05). Significant difference was found between the two groups according to growth style of tumor(exogenic:R17,N5;infiltrative:R6,N13;ulcerous R15,N17; P <0.05). Conclusion: These findings suggest that none were more useful in predicting tumor response than the growth style of tumor.