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儿童费城染色体阳性急性淋巴细胞白血病诊断治疗进展 被引量：1

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摘要 众所周知,儿童急性淋巴细胞白血病（acute lymphocytic leukemia,ALL）的治疗疗效近几十年来有了明显提高,其总体长期无病生存率（disease free survival,DFS）已达80％,但是高危患儿仅在30％～40％左右,尤其是费城染色体阳性的ALL（Philadephia chromosome,Ph＋ ALL）的长期无病生存率更低.近十年来,酪氨酸激酶抑制剂的应用给这些患儿的治疗带来了曙光,新的基因突变及基因组研究也正在改变我们之前对ALL遗传基础的理解.本文就此方面的进展作一综述.
作者 赵卫红 卢新天
机构地区 北京大学第一医院儿科
出处 《中国小儿血液与肿瘤杂志》 CAS 2013年第4期145-147,152,共4页 Journal of China Pediatric Blood and Cancer
关键词 儿童急性淋巴细胞白血病 费城染色体 诊断治疗 阳性 长期无病生存率 酪氨酸激酶抑制剂 治疗疗效 遗传基础
分类号 R733.71 [医药卫生—肿瘤]
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参考文献27

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同被引文献23

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中国小儿血液与肿瘤杂志
2013年 第4期

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