用于微流控PCR的TEC温控系统结构优化设计

Optimization design of structure of TEC temperature control system for microfluidic PCR

为了实现微流控聚合酶链式反应(PCR)的快速升降温,设计了一种基于半导体制冷片(TEC)的温度控制系统。通过对控温对象微流控PCR芯片的热分析,确定了TEC的参数,并且研究了TEC效率与散热性能之间的关系。在此基础上,设计了一种热管鳍片式高性能散热器,对其传热机理、传热路线及热阻进行了深入分析,建立了有限元模型,并对该热管散热器进行了实验测试。实验结果表明:该温控系统的平均升降温速率达到7.48℃/s,为实现微流控PCR系统的快速精确升降温控制奠定了良好基础。

In order to achieve rapid heating and cooling of microfluidic polymerase chain reaction（PCR）,a temperature control system is designed based on thermoelectric cooler（TEC）.Through thermal analysis on microfluidic PCR chip of temperature controlling object,parameters of TEC are determined,as well as the relationship between the cooling efficiency and heat radiation performance are studied.On this basis,a fin-type heat pipe high performance heat radiator is designed,its mechanism of heat transfer,the heat transfer routes,and thermal resistance are analyzed,finite element model（FEM） is set up,and experimental test on heat pipe heat radiator is carried out.The experimental results indicate that the average heating and cooling rate of temperature control system can achieve 7.48 ℃/s,and lay a good foundation for quickly and accurately heating and cooling temperature control of microfluidic PCR system.