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胰岛素样生长因子I的基础与临床研究进展 被引量:25

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摘要 胰岛素样生长因子I(IGF I)基因核苷酸序列分析揭示它含有 6个外显子 ,成熟的IGF I含有B、C、A、D 4个功能区 ,和IGF I受体相结合可发挥其促有丝分裂、促进生长分化及胰岛素样代谢效应 ,IGF I生物学活性受IGF I受体及IGF I结合蛋白调节。文中还进一步阐述了IGF I的临床意义 ,如临床治疗生长激素 (GH)获得性抵抗、GH不敏感综合征等生长障碍、糖尿病、极度胰岛素抵抗。
出处 《国外医学(内分泌学分册)》 2000年第6期302-305,共4页 Foreign Medical Sciences(Section of Endocrinology)
基金 国家自然科学基金资助项目!(基金号 39770 355)
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参考文献18

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