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血栓弹力图对冠脉介入患者抗血小板疗效的监测价值 被引量：2

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摘要 目的探讨经皮冠状动脉介入治疗(PCI)患者中,使用血栓弹力图(TEG)所测定的血小板抑制率的变化及临床意义。方法选取197例冠脉支架植入术患者,根据应用美国Hamo scope公司的TEG分析仪测定其ADP途径诱导的血小板抑制率值,根据血栓弹力图仪所测ADP诱导抑制率差异分为3组,>70%划入达标组(A组),ADP抑制率小于30%划入未达标组;入选未达标组患者随机分为2组,一组为大剂量组(B组),加用阿司匹林300 mg/d,1月后改用100 mg/d,长期服用;同时改氯吡格雷为100 mg/d,长期服用。另一组(C组)保持常规剂量不变。随访6个月记录一般情况及严重心脏不良事件(MACE)。结果半年随访期内共发生MACE事件28例,其中A组10例(9.7%),B组7例(15.2%),C组11例(22.9%);3组中MACE发生率C组>B组>A组,差异有统计学意义(P<0.05)。结论 TEG测定的血小板抑制率对于冠脉支架植入术后患者的抗血小板药物治疗方案的选择及预后的判断有一定的指导意义。
作者 刘如辉 许嘉鸿 李铭 黄飞飞 石炜祺
机构地区 上海市同济医院心内科
出处 《河北医药》 CAS 2013年第16期2435-2436,共2页 Hebei Medical Journal
关键词 血栓弹力图 血小板抑制率 经皮冠状动脉介入治疗
分类号 R443 [医药卫生—诊断学]
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参考文献6

  • 1Wenaweser P, Dorffler M J, Imboden K, et al. Stent thrombosis is associat- ed with an impaired response to antiplatelet therapy. J Am Coil Cardiol, 2005,45 : 1748-1752.
  • 2Hobson AR, Agarwala RA, Swallow RA, et al. Thrombelastography : cur- rent clinical applications and its potential role in interventional cardiolo- gy. Platelets ,2006,17:509-518.
  • 3Lev EI, Patel RT, Maresh KJ. Aspirin and clopidogrel drug response in patient s undergoing percutaneous coronary intervention:the role of dual drug resistance. J Am Coil Cardiol,2006,47:27-33.
  • 4Differding JA ,Underwood SJ ,Van PY ,et al. First place Residents' Com- petition: trauma induces a hypercoagulable state that is resistant to hypo- thermia as measured by thrombelastogram. Am J Surg,2011,201:585- 589.
  • 5Gurbel PA, Bliden KP, Naviekas IA, et al. Adenosine diphosphate in- duced platelet-fibrin clot strength : a new thrombelastographic indicator of long-term post stenting ischemic event. Am Heart J,2010, 160: 346- 354.
  • 6Gurbel PA, Becker RC, Mann KG, et al. Platelet function monitoring in patients with coronary artery disease. J Am Coil Cardiol, 2007,50:1822- 1834.

同被引文献22

  • 1Windecker S, Kolh P, Alfonso F, et al. 2014 ESC/EACTS Guidelines on myocardial revaseularization [ J ]. Rev Esp Cardiol ( Engl Ed ), 2015,68(2) :144.
  • 2Brar SS,Ten Berg J, Marcucci R, et al. Impact of platelet reactivity on clinical outcomes after percutaneous coronary intervention : A eollabora- tire meta-analysis of individual patieipant data [ J ]. JAMA, 2011,58 (19) :1945-1954.
  • 3Mehran R, Rao SV, Bhatt DL, et al. Standardized bleeding definitions for cardiovascular clinical trials:a consensus report from the Bleeding Academic Research Consortium [ J ]. Circulation, 2011,123 ( 23 ) : 2736-2747.
  • 4Gurbel PA,Tantry US. Do platelet function testing and genotyping im- prove outcome in patients treated with antithrombotie agents? : platelet function testing and genotyping improve outcome in patients treated with antithrombotie agents [ J ]. Circulation, 2012, 125 ( 10 ) : 1276- 1287.
  • 5Aradi D, Storey RF, Komocsi A, et al. Expert position paper on the role of platelet function testing in patients undergoing percutaneous coronary intervention[ J] Eur Heart J,2014,35(4) :209-215.
  • 6Vadasz D, Sztriha LK, Sas K, et al. Aspirin and clopidogrel resist- ance:possible mechanisms and clinical relevance. Part II:Potential causes and laboratm'y tests [ J ]. IdeggyogySz, 2013,66 ( 1-2 ) : 15 -22.
  • 7Sambu N, Adharishnan A, Dent H, et al. Personalised anti-platelet therapy in stent thrombosis:observations from the clopidogrel resist- ance in stent thrombosis (CREST) registry [ J ]. Heart, 2012,98 ( 9 ) : 706-711.
  • 8Godschalk TC, Hackeng CM, ten Berg JM. Towards Personalized Medicine Based on Platelet Function Testing for Stent Thrombosis Patients [ J ]. Thrombosis, 2012,2012 ( 12 ) : 617098.
  • 9Gurbel PA, Bilden KP, Navickas IA, et al. Adenosine Diphosphate-in- duced platelet-fibrin clot strength:A new thrombelastographic indica- tor of long-term post-stenting ischemic events [ J ]. Am Heart J,2010, 160(2) :346-354.
  • 10潘曙明,吴增斌,费爱华.血栓弹力图对急性脑梗死患者阿司匹林疗效监测价值[J].中华实用诊断与治疗杂志,2011,25(11):1078-1079. 被引量：27

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二级引证文献22

河北医药
2013年 第16期

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