氯氮平联合抗精神病药治疗精神分裂症阴性症状的效果分析

Analysis of efficacy of antipsychotics combined with clozapine orally disintegrating tablets in the treatment of schizophrenia with negative symptoms

目的探讨氯氮平口腔崩解片联合抗精神病药治疗精神分裂症阴性症状的效果及安全性。方法以阴性症状为主的精神分裂症患者50例,随机分为观察组(服用抗精神病药物联合氯氮平口腔崩解片)和对照组(单用抗精神病药物),各25例,疗程8周,按阳性与阴性症状量表(PANSS)及有关实验室检查结果评定疗效,分别于治疗前后各评定1次。结果观察组显效17例(68.0%),有效7例,无效1例;对照组显效10例(40.0%),有效12例,无效3例;观察组显效率高于对照组(P<0.05)。治疗8周后,两组各项评分均较治疗前明显下降(P<0.01);治疗后,观察组阴性症状分低于对照组(P<0.05)。结论抗精神病药物联合氯氮平口腔崩解片治疗以阴性症状为主的精神分裂症有较好的疗效,不良反应少。

Objective To explore the efficacy and safety of antipsychotics combined with clozapine orally disintegrating tablets in the treatment of schizophrenia with negative symptoms. Methods Fifty cases of schizophrenia mainly with negative symptoms were randomly divided into obsevation group （treated with antipsychotics and clozapine orally disintegrating tablets）and control group（ treated with antipsychotics）. The course of treatment was eight weeks. Indicators included Positive and Negative Symptoms Scale（PANSS） and Treatment Emergent Symptom scale（TESS） before and after treatment. Restults The significant improvement rate was higher in the observation group（68.0% ）than that of the control group （40%）. Eight weeks after treatment, the total scores and negative symptoms scores of PANSS were significantly lower in both observation groups than these of the patients before treatment（ P 〈 0.01 ）. The nega- tive symptom scores of the observation group was lower than that of the control group after treatment （ P 〈 0.05）. Conclusion Antip- syehotics combined with clozapine orally disintegrating tablets has better efficacy and less adverse reaction in the treatment of schizo- phrenia mainly with negative symptoms.