2型糖尿病与高龄老人良性前列腺增生症的关系研究

Relationship between type 2 diabetes mellitus and benign prostatic hyperplasia in elderly patients

目的探讨2型糖尿病(T2DM)与高龄老年人良性前列腺增生症(bengn prostatic hyperplasia,BPH)的关系。方法回顾性分析167例高龄BPH患者的临床资料,其中单纯BPH患者64例,T2DM合并BPH患者103例。收集血压、空腹血糖(FBG)、餐后2 h血糖(2 h PBG)、空腹胰岛素(FINS)、糖化血红蛋白(HbAlc)、血脂、血清前列腺特异性抗原(PSA)、国际前列腺症状评分(IPSS)及经腹部超声测量的前列腺体积(PV)等临床资料。结果单纯BPH组和T2DM合并BPH组,两组年龄、合并高血压及高脂血症情况比较,差异无统计学意义(P>0.05);与单纯BPH组相比,BPH合并T2DM组患者血清FINS、PSA、PV水平及IPSS评分显著升高(P<0.05)。BPH合并T2DM组中,不同水平FBG、2 h PBG患者的IPSS评分、PV与血清PSA,差异无统计学意义(P>0.05);BPH合并T2DM组中,HbA1c升高患者与HbA1c正常者比较,IPSS评分、PV与血清PSA明显升高(P<0.05)。结论T2DM是高龄患者BPH发生与进展的危险因素。

Objective To investigate the relationship between（BPH） and type 2 diabetes mellitus（T2DM）in elderly patients.Methods A total of 167 elderly BPH patients were recruited,including 64 cases of non-diabetic BPH and 103 cases of diabetic BPH.The blood pressure and international prostate symptoms score（IPSS）were documented;the prostate volume（PV）was examined by ultrasonography.Glycated hemoglobin（HbA1C）,FBG,FINS,blood lipid and serum prostate specific antigen（PSA） were measured.Results There were no differences in age,prevalence of hypertension and hyperlipidemia between non-diabetic BPH and diabetic BPH patients（P0.05）.The serum levels of FINS and PSA,PV and IPSS in diabetic BPH patients were higher than those in non-diabetic BPH patients（P0.05）.There were no differences in IPSS,PV and PSA at the different levels of FBG and 2h PBG in diabetic BPH patients（P0.05）.The level of IPSS,PV and serum PSA in diabetic BPH patients with abnormal HbAlc were higher than those in BPH patients with normal HbAlc（P0.05）.Conclusion T2DM might be a risk factor for the onset and development of BPH in elderly patients.