诺和锐30短期治疗对初发2型糖尿病患者胰岛β细胞功能的影响被引量：2

Effects of short-term Aspart 30 treatment on pancreatic β-cell function in patients with newly-diagnosed type 2 diabetes

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摘要目的探讨诺和锐30短期治疗对初发2型糖尿病患者胰岛β细胞功能和血糖控制的影响。方法采用自身对照的方法,对49例新诊断未治疗的2型糖尿病患者给予3个月的诺和锐30治疗,分析比较治疗前后血糖、胰岛素、C肽和胰岛素分泌功能各指标的变化。结果治疗后,空腹血糖、2 h血糖、糖化血红蛋白均明显下降,胰岛素分泌指数、胰岛素敏感指数均明显升高。胰岛素抵抗指数明显下降。结论诺和锐30治疗3个月可显著改善初发2型糖尿病患者的β细胞分泌功能和胰岛素敏感性,减轻胰岛素抵抗,改善糖代谢。 Objective To investigate the effects of short-term Aspart 30 treatment on pancreatic β- cell function and blood glucose control in patients with newly-diagnosed type 2 diabetes. Methods Forty nine patients with newly-diagnosed type 2 diabetes received Aspart 30 for three months. Levels in blood glucose, insulin, C-peptide were measured before and after treatmen. Results After treatment, fasting glucose, 2 h glucose and HbA1C were decreased significantly, insulin secretion index and insulin sensitivity index were significantly increased. Insulin resistance index decreased significantly. Conclusion Aspart 30 can significantly improve the β-cell secretory function, insulin sensitivity and glucose control in patients with newly-diagnosed type 2 diabetes.

作者李红梅唐兆生冯波

机构地区同济大学附属东方医院内分泌科

出处《同济大学学报（医学版）》 CAS 2013年第4期61-63,共3页 Journal of Tongji University(Medical Science)

关键词 2型糖尿病诺和锐30 胰岛Β细胞功能 type 2 diabetes Aspart 30 islet β-cell function

分类号 R587.1 [医药卫生—内分泌]

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1祝方,纪立农,韩学尧,朱宇,张红杰,周翔海,陈静,蔡晓陵,张明霞.短期胰岛素强化治疗诱导初诊2型糖尿病患者血糖长期良好控制的临床试验[J].中国糖尿病杂志,2003,11(1):5-9. 被引量：856
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4李延兵,翁建平,许雯,陈小华,廖志红,姚斌,邓婉萍,欧香忠,胡国亮.短期持续胰岛素输注治疗对初诊2型糖尿病患者胰岛β细胞功能的影响[J].中国糖尿病杂志,2003,11(1):10-15. 被引量：777

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