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阿托伐他汀下调肿瘤坏死因子-α诱导的人脐静脉内皮细胞NF-κB的表达 被引量：2

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摘要 阿托伐他汀（atorvastation，AT）作为一种有效的他汀类降血脂药，能够降低血清胆固醇和低密度脂蛋白，近年发现AT在病理生理学方面还具有抗炎、抗氧化及稳定动脉硬化斑块的作用，然而AT稳定动脉硬化斑块的确切机制至今尚未明了。NF-κB是一种重要的炎症、凋亡因子，作为多种炎症、细胞因子的中间环节，参与正负反馈调节机制，本实验拟研究AT稳定动脉硬化斑块与NF-κB表达、分泌之间的内在联系，探讨AT稳定动脉硬化斑块的作用机制，现报道如下。
作者 毛德军 崔君平 臧运华 唐咏春 郭瑞友
机构地区 青岛大学医学院附属海慈医疗集团神经内科 山东省青岛市盐业职工医院
出处 《细胞与分子免疫学杂志》 CAS CSCD 北大核心 2013年第10期1061-1063,共3页 Chinese Journal of Cellular and Molecular Immunology
关键词 内皮细胞 肿瘤坏死因子-Α 阿托伐他汀 核因子-ΚB
分类号 R392-33 [医药卫生—免疫学] R972.6 [医药卫生—药品]
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参考文献12

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二级参考文献50

共引文献76

同被引文献27

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  • 10李建英,路文盛,刘斐,郭进,陈健,叶伟林.阿托伐他汀对早期糖尿病肾病老年患者外周血NF-κB和尿白蛋白排泄率的影响[J].实用医学杂志,2011,27(11):1956-1958. 被引量：12

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细胞与分子免疫学杂志
2013年 第10期

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