加强围手术期综合治疗以提高食管癌的远期疗效

Strengthen perioperative multimodality treatment in order to improve long-term outcomes of esophageal cancer

食管鳞癌是我国常见病,手术是食管癌主要的治疗手段,但单一手术疗效并不理想.因此,旨在改善远期生存的围手术期治疗受到重视,包括局部治疗和全身治疗, 可在术前行诱导治疗,也可在术后行补充治疗.经过几十年的研究与实践,目前认为术前治疗于术后治疗,放化疗好于单一化疗或放疗.因此,术前诱导放化疗是改善局部晚期食管癌疗效的标准治疗手段与研究方向.

Esophageal squamous cell carcinoma （ESCC） is one of the commonest malignances in China.Surgery is the main treatment for ESCC.However,the longterm survival is very poor by surgery alone.Perioperative multimodality treatment,including locally and systemically administrated,preoperatively and postoperatively,has been and will be the standard treatment in terms of improving longterm survival.Base on decades of practice and clinical trials,it is believed that preoperative treatment is better than postoperative treatment,and that chemotherapy plus radiotherapy preoperatively is better than either chemotherapy or radiotherapy alone.Therefore,preoperative radiochemotherapy followed by surgery is the standard treatment and future direction for locally advanced ESCC.