青年人食管癌临床病理特征及预后

Clinicopathological characteristics and prognosis of young esophageal cancer patients

目的 探讨青年人与中老年人食管癌的临床病理特征及预后的差异.方法 回顾性分析1990年1月至1998年12月间在中山大学肿瘤防治中心接受手术治疗的716例食管鳞状细胞癌患者的临床资料,对其中117例45岁以下 （青年组）和599例大于45岁（中老年组）患者的临床病理特征及预后进行对比分析.结果 除肿瘤分期外,青年组与中老年组临床病理特征的差异均无统计学意义（均P＞0.05）.青年组Ⅲ期患者所占比例为47.9％（56/117）,明显高于中老年组的33.6％（201/599,P=0.010）.但青年组与中老年组患者的预后差异并无统计学意义（5年生存率：36.0％比33.8％,10年生存率：29.2％比25.0％,P=0.418）.多因素预后分析显示,患者年龄不是食管癌的独立预后因素 （P=0.160,RR=1.187,95％CI：0.935～1.506）.结论 尽管青年人食管癌的病理分期较晚,但其预后与中老年人并无明显差异.

Objective To compare the clinicopathological features and prognosis of esophageal cancer between young and elderly patients.Methods Clinical data of 716 patients with esophageal squamous cell carcinoma undergoing curative operation from January 1990 to December 1998 at the Cancer Center of Sun Yat-sen University were analyzed retrospectively.Clinicopathological features and prognosis of 117 patients aged ≤45 years （young group） at diagnosis were compared with 599 patients aged 〉45 years （elderly group）.Results Except for tumor stage,there were no significant differences of clinicopathology between the young group and the elderly group （all P〉0.05）.There were more pathologic stage Ⅲ cancer in the young group than the elderly group（47.9% vs.33.6%,P=0.010）.The 5-year survival rate （36.0% vs 33.8%） and 10-year survival rate （29.2% vs 25.0%） were not significantly different between the two groups （P=0.418）.Multivariate analysis showed that the age was not the independent prognostic factors of esophageal squamous cell carcinoma （P=0.160,RR=1.187,95%CI：0.935-1.506）.Conclusion Young esophageal cancer patients have more advanced tumors than elderly patients.However,the survival is comparable to the elderly.