阿曲库铵恢复期应用琥珀胆碱对其肌松恢复的影响

The Effect of Succinylcholine on the Recovery Period of Atracurium Blockade

目的:观察在阿曲库铵阻滞恢复期应用琥珀胆碱是否影响其肌松恢复时间。方法:40例择期眼科手术病人随机分为2组,即对照组和试验组分别为17和23例。TOF监测肌松,两组病人诱导过程中均用琥珀胆碱协助插管(TOF=0)。气管插管后T1恢复至对照值75%时两组病人均静注阿曲库铵0.5mg/kg维持肌松,组Ⅰ对照,组Ⅱ当T1恢复至对照的50%时静注琥珀胆碱1～1.5mg/kg,监测起效时间、临床肌松维持时间、50%恢复时间、75%恢复时间和肌松类型。结果:两组病人阿曲库铵阻滞后,临床肌松维持时间、50%恢复时间、75%恢复时间组间无显著差异。结论:并用非去极化肌松药维持全麻过程中,当T1恢复到50%时使用琥珀胆碱不延长肌松恢复时间。

To study the effet of succinylcholine on the recovery period of atracurium blockade. Methods:Forty patients undergoing selective ophthalmic surgery were randomly divided into a test group( n = 23)and a control group( n= 17). In order to measure neuromuscular responses during anesthesia, the stimulation used were train-of-four(TOF) . In both groups, anesthesia was induced with succinylcholine( 1~1.5 mg/kg, iv). A tracheal intubation was performed during a maximum depression(TOF= 0) . When T1 of TOF returned to 75% of its original baseline,the both groups received atracurium(0.5 mg/kg) . When Tl returned to 50 % , the test group received succinylchline (1~ 1.5 mg/kg) . The parameters included onset time,duration of action,50% recovery time,75% recovery time and neuromuscular blocking patterns. Results:There was no significant difference between the respective duration of action, 50 % recovery time and 75 % recovery time of the two groups. Conclusion: Succinylcholine had no significant prolonged effect on the recovery of atracurium.