IDDM牙周病患者龈沟液IL-1β的检测与分析

Measurement and Analysis of IL-1β in Gingival Crevicular Fluid from Periodontal Diseases in IDDM Patients.

目的 :比较胰岛素依赖性糖尿病 (IDDM)牙周病患者与全身健康者龈沟液IL - 1β的差异及这一炎症介质水平与糖代谢状况的关系。方法 :用ELISA法测龈沟液IL - 1β水平 ,同时测IDDM病人糖化血红蛋白 (HbA1c)浓度。结果 :IDDM病人龈沟液IL - 1β含量明显高于对照组 ,中重度牙周炎中这一炎症介质浓度明显高于轻度牙周病。龈沟液IL - 1β水平不与反映糖代谢控制状况的糖化血红蛋白浓度相关。 结论 :龈沟液IL - 1β水平在受局部环境影响的同时 ,也受全身因素调控。糖尿病人因全身反应异常 ,龈沟液IL - 1β会大幅度上升 ,从而导致重度牙周炎发生。

Objective: To compare the IL-1β level in gingival crevicular fluid (GCF) from periodontal diseases in insulin dependent diabetes mellitus (IDDM) with that from systemically healthy person and the relationship between GCF- IL-1β concentration and metabolic condition. Methods: The content of IL-1β was measured by ELISA. The HbA1c con centration in IDDM patients was analysed. Results: Diabetics had significantly higher GCF-IL-1β level as compared to controls. The GCF contents of this inflammatory mediators were significantly highter in moderate or severe periodontal disease patients than that in mild periodontal disease subjects. The GCF-IL-1β did not correlate with HbA1c levels. Conclusions: The GCF-IL-1β level was controled by both local circumstances and systemic factors. The high GCF-IL-1β contents in diabetics may be a consequence of a systemic abnormal response and a more severe periodontal disease may thus be resulted. [