摘要
慢性乙型肝炎(chronic hepatitis B,CHB)抗病毒治疗持续应答(sustained response,SR)的预测依然是有待深入探讨的重要临床问题。近年来认识到HBsAg定量是一种非常重要的SR预测因子,也是CHB抗病毒治疗终点最理想的判断指标。本文全面介绍了慢性HBV感染者血清HBsAg水平的自然变化趋势、影响因素及其与抗病毒治疗的关系。
Prediction of sustained response (SR) to antiviral treatment in patients with chronic hepatitis B (CHB) remains an important clinical problem to be' deeply investigated. In recent years, HBsAg quantification has been recognized as a potent predictor of SR and an ideal endpoint of antiviral treatment for CHB. This article focuses on the natural trend of serum HBsAg level during chronic HBV infection, influential factors of HBsAg level and the correlation hetween serum HBsAg level and antiviral therapy in CHB patients.
出处
《传染病信息》
2013年第4期253-258,共6页
Infectious Disease Information
基金
南京军区"十一五"医药科技项目(09Z011
06MA63)
关键词
乙型肝炎表面抗原
乙型肝炎
慢性
治疗学
hepatitis B surface antigens
hepatitis B, chronic
therapeutics