梅毒少见的临床表现

Rare clinical manifestations of syphilis

由于抗生素的不规范使用，同性恋人群性行为的变化，合并HIV感染，孕期梅毒未发现及孕期前后3个月内未给予苄星青霉素治疗等因素，均可导致梅毒感染者发生皮肤黏膜、骨关节、心血管系统、神经系统、消化系统及呼吸系统少见或不典型病变，给诊断及治疗带来困难。概述近年来报道的梅毒少见临床表现，为临床医生提供更广泛的思路，及早发现及诊断梅毒，减少梅毒引起的系统性损害。

Due to non-standardized administration of antibiotics, changes in homosexual behavior, human immunodeficiency virus co-infection, missed diagnosis of syphilis during pregnancy, and non-administration of benzathine benzylpenicillin for syphilis treatment in the first and last three months of pregnancy, many uncommon or rare manifestations haven been observed in syphilitic patients with the involvement of skin, mucous membrane, bone, joints, cardiovascular system, nervous system, alimentary system and respiratory system, which increases difficulties in the diagnosis and treatment of syphilis. This paper presents atypical syphilis cases reported at home and abroad in recent years, in hope to enhance clinicians＂ understanding of syphilis, so as to facilitate early diagnosis of svohilis and reduce systemic damages caused by syphilis.