新型咪唑类抗真菌外用药物卢立康唑

Luliconazole, a novel topical antifungal imidazole

卢立康唑是一种新型的咪唑类抗真菌外用药物。体内外实验研究及临床研究显示，卢立康唑对皮肤癣菌、白念珠菌、马拉色菌和部分相对少见的暗色及透明丝状真菌均表现出较高的抗真菌活性，对红色毛癣菌的最小抑菌浓度（MIC50）低至0．00024μg／ml。在日本，1％卢立康唑膏剂和溶液已被批准用于包括皮肤癣菌感染、皮肤念珠菌病和花斑糠疹等浅部真菌感染的治疗。

Luliconazole is a novel, optically active, topically applied antifungal imidazole. In vitro and in vivo experimental studies and clinical studies have revealed that luliconazole has a strong wide-spectrum antifungal activity against Dermatophytes spp., Candida albicans, Malassezia spp., and some uncommon pathogens including dematiaceous fungi and hyalohyphomycetes. The 50% minimun inhibitory concentration （MICs0） of luliconazole against Trichophyton rubrum can be as low as 0.00024 ug/ml. In Japan, lulieonazole 1% cream/solution has been approved for the treatment of superficial fungal infeetions including dermatophytosis, cutaneous candidiasis, and pityriasis versicolor.