肿瘤相关巨噬细胞在恶性皮肤肿瘤侵袭进展中的作用

Roles of tumor-associated macrophages in the invasion and progression of malignant cutaneous tumors

肿瘤的发生发展是一个复杂的病理过程，包括肿瘤细胞的生长、侵袭和转移。肿瘤微环境中的巨噬细胞或许不再具有其原有的选择性杀伤肿瘤细胞的作用，而是通过其分泌的一系列细胞因子促进肿瘤细胞的生长、侵袭和转移，甚至有助于肿瘤细胞的免疫逃逸。越来越多的研究证实，肿瘤相关巨噬细胞的数量和功能与某些皮肤恶性肿瘤的预后具有相关性。

Tumor initiation and progression is a complex pathological process including the growth, invasion and metastasis of tumor cells. Macrophages in tumor microenvironment may fail to selectively destruct tumor cells, hut can secret a series of cytokines to promote tumor cell growth, invasion, metastasis, and even escape from the normal immune system. Recently, more and more studies have demonstrated that the quantity and function of tumor-associated macrophages are related to the prognosis of some cutaneous malignancies.