海洛因成瘾者尾状核静息态功能连接的fMRI改变

Alteration of functional connectivity of caudate nucleus in heroin-dependent individuals-a resting state fMRI study

目的以尾状核为感兴趣区进行静息态功能连接分析,研究与海洛因成瘾相关的静息态功能连接异常。方法以15名男性慢性海洛因成瘾者以及15名年龄、性别和香烟吸食量相当的健康对照作为研究对象。以3.0T磁共振对受试者进行静息态功能磁共振(fMRI)扫描,利用SPM软件分析两组被试的静息态数据,并在全脑范围内定位与尾状核存在功能连接的脑区。比较成瘾组与健康组之间尾状核功能连接差异。将差异脑区与尾状核之间的功能连接度与海洛因成瘾者吸食毒品时间进行相关分析。结果与健康对照组相比,成瘾组尾状核与豆状核、杏仁核以及海马之间的功能连接强度明显上升(t=2.8,P<0.005;voxel>5),而与前扣带回的功能连接却显著降低(t=2.8,P<0.005)。左侧杏仁核以及右侧海马与尾状核之间的功能连接度与吸食毒品的时间正相关(r=0.68,P<0.05;r=0.59,P<0.05)。结论海洛因成瘾后涉及奖赏、记忆以及动机脑功能区之间的静息态功能连接上升,涉及认知控制功能的脑区之间功能连接下降,可能与海洛因成瘾相关。

Objective To investigate the resting-state abnormalities of heroin addiction by analyzing resting-state functional connectivity of the caudate nucleus. Methods Fifteen male chronic heroin users and 15 age-, gender- and nicotine dependence-matched healthy subjects participated in the present resting-state functional connectivity analysis. All the participants undertook a resting-state fMRI scan with GE 3. 0 T scanner and the obtained data were analyzed by Statistical Parametric Mapping （SPM） software. Functional connectivity was analyzed based on resting-state fMRI data to identify the correlation between the caudate and the other regions on the whole brain scale by SPM. Finally, t-test was applied to determine the functional connectivity of the caudate between the two groups. The relationship between the connectivity of specific regions and heroin-dependence period was investigated. Results Compared with the healthy control group, the caudate of heroin- dependent group had significantly enhanced functional connectivities with the lentiform nucleus, amygdala, hippocampus （t = 2.8, P〈0. 005;voxel〉5） and significantly decreased functional connectivity with the dorsal anterior cingulate cortex （t= 2.8, P〈0. 005）. Besides, the functional connectivity between the caudate and left amygdala （r= 0. 68, P〈0. 05） and right hippocampus （r=0.59, P〈0.05） was positively correlated with the duration of heroin use. Conclusion The resting functional connectivities of the brain regions for rewarding, memory and motivation/drive are increased after heroin dependence, and those of the cognitive control region are decreased, which might be related to heroin dependence.