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老年人杓型高血压晨峰现象与尿蛋白和肌酐的关系 被引量:8

Relationship between morning blood pressure surge and urinary albumin creatinine ratio in elderly patients with dipper essential hypertension
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摘要 目的探讨老年杓型高血压患者血压晨峰(morningbloodpressuresurge,MBPS)现象与尿微量白蛋白/肌酐(UmAlb/Cr)的关系。方法273例老年杓型高血压患者,根据动态血压监测有无MBPS现象分为晨峰组106例及非晨峰组167例,均进行UmAlb/Cr检测,并常规检测血尿素、肌酐、血糖、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、三酰甘油、胆固醇,分析两组间UmAlb/Cr差异。结果两组患者在性别比、年龄、高血压病程、血尿素、肌酐、血糖、HDL-C、LDL-C、三酰甘油、胆固醇比较差异均无统计学意义(P〉0.05)。晨峰组与非晨峰组比较,MBPS变异幅度显著增高[(32.8±8.2)mmHg比(12.0±7.2)mmHg,P=0.003。晨峰组umAlb/cr高于非晨峰组(4.93±2.17比4.23±2.42,P=0.01),晨峰组不同性别UmAlb/Cr均高于非晨峰组(男性:4.95±1.96比2.98±2.05,P=0.001;女性:5.89±2.24比5.03±2.37,P=0.04)。结论老年杓型高血压患者MBPS现象对UmAlb/Cr增高产生重要影响,有晨峰现象高血压患者易早期发生肾功能损害。 Objective To investigate the relationship between morning blood pressure surge (MBPS) and urinary albumin/creatinine (UmAlb/Cr) ratio in elderly patients with dipper essential hypertension. Methods Totally 273 elderly patients with dipper essential hypertension were divided into MBPS group (observation group, n= 106) and non-MBPS group (control group, n-- 167) according to the presence or absence of MBPS. The urinary UmAlb/Cr ratio, blood urea nitrogen (BUN), creatinine (Cr), blood glucose (Glu), high density Iipoprotein cholesterol (HDLC), low density lipoprotein cholesterol (LDL-C), triglyceride (TG) and cholesterol (TCH) were detected. The differences in UmAlb/Cr ratio between the two groups were analyzed. Results There were no statistical significances in sex ratio, age, course of hypertension, BUN, Cr, blood Glu, HDL-C, LDL-C, TG and TCH between the two groups (P〉0.05). The amplitude of variation in morning systolic pressure peak was higher in MBPS group than in non MBPS group ((32.8±8.2) mmHg vs. (12.0±7.2) mm Hg,P〈0. 001. UmAlb/Cr ratio was higher in MBPS group than in non-MBPS group (4. 93±2.17) vs. (4.23±2.42), P〈0. 059. There were significant differences in UmAlb/Cr ratio between MBPS group and non-MBPS group in different genders male: (4.95±1.96) vs. (2.98 ±2.05), female: (5.89±2.24) vs. (5.03±2.37), both P〈0.05. Conclusions MBPS has a great influence on UmAlb/Cr ratio and tends to cause early impairment Of renal function in elderly patients with dipper essential hypertension.
出处 《中华老年医学杂志》 CAS CSCD 北大核心 2013年第9期937-939,共3页 Chinese Journal of Geriatrics
关键词 高血压 白蛋白尿 肌酐 Hypertension Albuminuria Creatinine
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