CREB信号通路在神经系统中的调控及功能

The Regulation of CREB Signaling Pathway in Nervous System Functions

cAMP应答元件结合蛋白(cAMP response element binding protein,CREB)在神经元生成、突触可塑性及学习记忆等方面都具有重要的调节作用,这使得与CREB信号通路相关的分子成为较受关注的神经系统疾病干预的药物靶点.本文概述了CREB的基本构成、相关信号通路、其目的基因表达调控及其在阿尔茨海默病(Alzheimer’s disease,AD)中的作用.

The cAMP response element binding protein （CREB） is a nuclear regulatory factor in eukaryotic cells. CREB is one of eight subtypes of the CREB/ATF family. CREB contains two regions in the structure, a N-terminal region which regulates transcription and a C-terminal region which binds to promoters of target genes. CREB can be regulated through many signaling pathways, such as cAMP, MAPK, and Ca2＋ -CaMK pathways. CREB phosphorylation is required for the transcription modulation in various neuronal processes, including neurogenesis, synaptic plasticity, learning and memory. CREB and its regulatory factors can be attractive drug candidates for nervous system diseases. As the role of CREB in memory and learning drew much attention in recent years. This review summarizes recent discoveries in structural analysis, related signaling pathways, and target gene expression of CREB, especially in Alzheimer＇ s disease.