急性冠脉综合征患者血清高敏C反应蛋白和组织蛋白酶S水平变化与临床意义

Changes of hs-CRP,CatS level in acute coronary syndrome patients serum and clinical significance

目的:探讨血清高敏C反应蛋白(hsCRP)、组织蛋白酶S(CatS)与急性冠脉综合征的相关关系。方法:选择53例急性冠脉综合征患者(ACS组),对照组36例,检测两组血清CatS、hs-CRP水平并进行比较。同时检测ACS组治疗后血清hs-CRP、CatS水平的变化。结果:ACS组在性别、年龄、吸烟、糖尿病、脑梗死、高血压患病率方面与对照组相比,差异无统计学意义(P>0.05);ACS组治疗前血清CatS水平为(0.51±0.03)nmol/L,hs-CRP为(10.21±5.03)mg/L,分别高于对照组的(0.43±0.04)nmol/L和(3.64±1.87)mg/L,差异具有统计学意义(P<0.05);ACS组治疗后血清CatS、hs-CRP水平分别为(0.45±0.06)nmol/L和(6.05±3.25)mg/L,较治疗前的(0.51±0.03)nmol/L和(10.21±5.03)mg/L明显降低,差异有统计学意义(P<0.05)。结论:ACS患者血清CatS及hs-CRP的水平的变化提示CatS及hs-CRP可能在ACS发生发展过程中具有重要作用,推测CatS可能作为ACS的一种新的生物标志物。

AIM： To investigate the serum high sensitive creactive protein （hs-CRP）, ca-thepsin S （CatS） level changes and clinical sig- nificance in acute coronary syndrome patients.METHODS： All patients were divided into acute coronary syndrome （ACS group, n= 53） and control group（n= 36）. The levels of serum hs- CRP and CatS in two groups were detected and compared before and after treatment. RESULTS： There were no significant difference of two groups in gender, age, smoking, diabetes, cere- bral infarction, hypertension prevalence rate. The levels of serum CatS and hs-CRP in ACS group before treatment and control group were （0.51±0.03） nmol/L, （10.21±5.03） mg/L and （0.43 ± 0.04） nmol/L, （3.64 ± 1.87） rag/L, respectively there were statistically sig- nificant differences （P〈 0.05 ）. After treatment, the levels of serum Cats and hs-CRP in ACSgroup were （0.45±0.06） nmol/L and （6.05± 3.25） mg/L, compared with before treatment （0.51± 0.03） nmol/L and （10.21± 5.03） mg/L, which were significantly decreased, there were statistically significant differences （P〈0.05）. CONCLUSION： Changes of hs-CRP, CatS level in ACS patients suggest that hs-CRP and CatS may play an important role in acute coronary syndrome, CatS may possibly act as a new biomarker of ACS. KEY WORDS Cathepsin S; Acute coronary syndrome; High sensitive creactive protein