肽基脯氨酰顺反异构酶在子宫内膜癌组织中的表达及与PR蛋白的关系

Expression of pin1 in endometrial carcinoma and its relation with PR

目的探讨肽基脯氨酰顺反异构酶（peptidyl prolyl cis-trans isomerase，Pin1）蛋白在子宫内膜癌组织中的表达与临床病理特征的关系，及其与病程相关蛋白的（PR）表达的相关性。方法回顾性分析湘雅医院 2010年2月~2012年10月收治50例子宫内膜癌临床病理资料，采用免疫组织化学方法对子宫内膜癌组织中pin1及PR蛋白的表达进行检测，结果采用卡方检验及Spearman相关系数法进行统计学分析。结果 pin1蛋白在子宫内膜癌中的阳性表达率为66%（33/50），其表达阳性率随着病理分化程度由高到低依次递减（高分化组93.3%，中分化组 84.6%，低分化组36.4%），浅肌层浸润组pin1阳性表达率（77.4%）显著高于深肌层浸润组（47.4%），淋巴结转移组pin1阳性表达率（28.6%）显著低于淋巴结未转移组（72.1%）。pin1与PR阳性表达呈现正相关（P〈0.05）。结论 pin1蛋白表达增高可能与子宫内膜癌的病理分化程度、肌层浸润深度及淋巴结转移有关，有望与PR一起成为预测子宫内膜癌患者治疗效果的一个重要的指标。

Objective To inverstigate the clinicopathologic significance of pin1 and PR in patients with endometrial adenocarcinoma. Methods The expression of pin1 and PR were investigated by immunohistochemistry in a total of 50 endometrial adenocarcinoma specimens. Results Pin1 was over expressed in 66%（33/50） of the cases. The expression rate decreased gradually with tumor differentiation（P〈0.05）. In addition, pin1 expression was negatively correlated with lymph node metastasis and invasive depth of myometrium. Moreover, pin1 was positively correlated with PR expression. Conclusion Our results suggest that pin1 may play important roles in the tumorigenesis and migration of endometrial cancer. Pin1 expression may be considered as a prognostic marker as PR in patients with endometrial cancer.