摘要
慢性。肾脏病(CKD)是严重危害人类健康的常见病,已成为全球公共健康问题。流行病学资料显示,心血管疾病(cardiovascular disease,CVD)是CKD最常见的严重并发症。其中,血管钙化广泛发生于CKD患者中,是导致其CVD发病率和病死率显著增加的重要危险因素。因此,深入探讨CKD血管钙化的发病机制,对于积极防治CKD的心血管并发症具有重要意义。
出处
《中华医学杂志》
CAS
CSCD
北大核心
2013年第34期2759-2761,共3页
National Medical Journal of China
参考文献40
-
1Sage AP, Tintut Y, Demer LL. Regulatory mechanisms invascular calcification. Nat Rev Cardiol, 2010, 7: 528-536.
-
2Russo D, Palmiero G, De-Blasio AP, et al. Coronary artery' calcification in patients with CRF not undergoing dialysis. Am J Kidney Dis, 2004, 44 : 1024 -1030.
-
3Tomiyama C, Carvalho AB, Higa A, et al. Coronary calcification is associated with lower bone formation rate in CKD patients not yet in dialysis treatment. J Bone Miner Res, 2010, 25: 499-504.
-
4Cannata-Andia JB, Rodriguez-Garcia M, Carrillo-Lopez N, et al. Vascular calcifications : pathogenesis, management, and impact on clinical outcomes. J Am Soe Nephrol, 2006, 17: S267-S273.
-
5Amann K. Media calcification and intima calcification are distinct entities in chronic kidney disease. Clin J Am Soc Nephrol, 2008, 3 : 1599-1605.
-
6Persy V, D'Haese P. Vascular calcification and bone disease: the calcification paradox. Treads Mol Med,2009,15:405-416.
-
7London GM, Guerin AP, Marchais SJ, et al. Arterial media calcification in end-stage renal disease: impact on all-cause and cardiovascular mortality. Nephrol Dial Transplant, 2003, 18 : 1731-1740.
-
8Kovesdy CP, Ureche V, Lu JL, et al. Outcome predictability of serum alkaline phosphatase in men with pre-dialysis CKD. Nephrol Dial Transplant, 2010, 25: 3003-3011.
-
9Skolnick AH, Osranek M, Formica P, et al. Osteoporosis treatment and progression of aortic stenosis. Am J Cardiol, 2009, 104 : 122-124.
-
10Thompson B, Towler DA. Arterial calcification and bone physiology: role of the bone-vascular axis. Nat Rev Endocrinol, 2012, 8 : 529-543.
二级参考文献28
-
1李占园,刘毅,王文靖,徐玉兰.高磷对牛血管平滑肌细胞钙化及其骨桥素分泌的影响[J].中华肾脏病杂志,2006,22(1):52-53. 被引量:1
-
2Coladonato J. Control of hyperphosphatemia among patients with ESRD. J Am Soc Nephrol, 2005, 16 Suppl 2: S107- S114.
-
3Block GA. Control of serum phosphorus: implications for coronary artery calcification and calcific uremic arteriolopathy (calciphylaxis). Curr Opin Nephrol Hypertens, 2001, 10: 741-747.
-
4Ishimura E, Okuno factors for vascular between diabetics S, Taniwaki H, et al. Different risk calcification in end-stage renal disease and nondiabetics: the respective importance of glycemic and phosphate control. Kidney Blood Press Res, 2008, 31: 10-15.
-
5Wang N, Yang J, Yu X, et al. Radial artery calcification in end-stage renal disease patients is associated with deposition of osteopontin and diminished expression of alpha-smooth muscle actin. Nephrology (Carlton), 2008, 13: 367-375.
-
6Li X, Giachelli CM. Sodium-dependent phosphate cotransporters and vascular calcification. Curr Opin Nephrol Hypertens, 2007, 16: 325-328.
-
7Raggi P, Kleerekoper M. Contribution of bone and mineral abnormalities to cardiovascular disease in patients with chronic kidney disease. Clin J Am Soc Nephrol, 2008, 3: 836-843.
-
8Prince M, Banerjee C, Javed A, et al. Expression and regulation of Runx2/Cbfa1 and osteoblast phenotypie markers during the growth and differentiation of human osteoblasts. J Cell Bioehem, 2001, 80: 424-440.
-
9Pagani F, Francucci CM, Moro L. Markers of bone turnover: biochemical and clinical perspectives. J Endoerinol Invest, 2005, 28: 8-13.
-
10Jono S, McKee MD, Murry CE, et al. Phosphate regulation of vascular smooth muscle cell calcification. Circ Res, 2000, 87: e10-e17.
共引文献19
-
1闫铁昆,林珊,贾俊亚,商文雅,韦丽.尿毒症患者桡动脉盐皮质激素受体表达与血管钙化的关系[J].中华肾脏病杂志,2010,26(3):181-186. 被引量:12
-
2卢宏涛,谌卫,张优,张欢,刘康,吴海洋,吴灏,郭志勇.血清FGF-23与维持性血液透析患者透中低血压发生的关系[J].中国中西医结合肾病杂志,2014,15(4):314-317. 被引量:3
-
3张明慧,王本泉,蔡晓青,刘彪,王斯璐,吴存造,白永恒,陈必成,刘毅,邵蓉蓉.白藜芦醇抑制血管平滑肌细胞成骨样转化的实验研究[J].中草药,2014,45(10):1444-1449. 被引量:6
-
4王玲,田野,闫红霞,王元见.冠心病患者发生室性心律失常时血清CD40配体和肿瘤坏死因子-α及白细胞介素-6水平变化及意义[J].中华实用诊断与治疗杂志,2015,29(4):393-395. 被引量:16
-
5程晨,王宁宁,查小明.不同外科术式治疗严重继发性甲状旁腺功能亢进的比较[J].中华肾脏病杂志,2015,31(4):314-320. 被引量:20
-
6郑淑蓓,金领微,周志宏.维持性血液透析患者血清分泌型Klotho蛋白与冠状动脉粥样硬化的关系[J].温州医学院学报,2015,45(4):281-285. 被引量:4
-
7郑淑蓓,金领微,李占园,周志宏.维持性血液透析患者冠状动脉钙化的评价及影响因素分析[J].中华肾脏病杂志,2015,31(5):339-344. 被引量:23
-
8陶静,贺倩,孙伟.维持性血液透析患者血管钙化的研究进展[J].中华肾脏病杂志,2015,31(7):548-552. 被引量:10
-
9贾瑞丽,吴晓磊,傅淑霞,田莉,谭会斌.腹膜透析患者血清可溶性Klotho蛋白与腹主动脉钙化关联性的研究[J].肾脏病与透析肾移植杂志,2015,24(3):231-236. 被引量:3
-
10仲思,范秋灵,卢新星,苏彦,张东成,王力宁.血清可溶性KLOTHO蛋白与腹膜透析患者矿物质骨代谢及腹主动脉钙化相关性的研究[J].中国血液净化,2015,14(9):525-529. 被引量:5
同被引文献37
-
1Sbobeiri N, Adams MA, Holden RM. Phosphate: an old bone molecule but new cardiovascular risk factor[J]. Br J Clin Pharmacol, 2014,77 ( 1 ) : 39-54.
-
2Marks J, Debnam ES, Unwin RJ. The role of the gastrointestinal tract in phosphate homeostasis in health and chronic kidney disease[J]. Curr Opin Nephrol Hypertens,2013, 22(4) : 481-487.
-
3Waheed AA, Pedraza F, Lenz O, et al. Phosphate control in end-stage renal disease: barriers and opportunities[J]. Nephrol Dial Transplant,2013,28(12) :2961-2968.
-
4Palmer SC, Hayen A, Macaskill P, et al. Serum levels of phosphorus, parathyroid hormone, and calcium and risks of death and cardiovascular disease in individuals with chronic kidney disease: a systematic review and meta-analysis [J]. JAMA,2011,305(11): 1119-1127.
-
5Bellasi A, Mandreoli M, Baldrati L, et al. Chronic kidney disease progression and outcome according to serum phosphorus in mild to-moderate kidney dysfunction [J]. Clin J Am Soc Nephrol, 2011,6(4) :883-891.
-
6Floege J, Kim J, Ireland E, et al. Serum iPTH, calcium and phosphate, and the risk of mortality in a European haemodialysis population[J]. Nephrol Dial Transplant, 2011, 26 (6): 1948- 1955.
-
7Voormolen N, Noordzij M, Grootendorst DC, et al. High plasma phosphate as a risk factor for decline in renal function and mortality in pre-dialysis patients[J]. Nephrol Dial Transplant, 2007,22(10) :2909-2916.
-
8Chue CD, Edwards NC, Davis LJ, et al. Serum phosphate but not pulse wave velocity predicts decline in renal function in patients with early chronic kidney disease[J]. Nephrol Dial Transplant, 2011,26 (8): 2576-2582.
-
9Sekiguchi S, Suzuki A, Asano S, et al. Phosphate overload induces podocyte injury via type III Na-dependent phosphate transporter[J]. Am J Physiol Renal Physiol, 2011,300 (4) :F848-856.
-
10Shroff R. Phosphate is a vascular toxin[J]. Pediatr Nephrol, 2013,28(4) :583-593.
引证文献3
-
1余毅,魏培丹.核心结合因子α-1基因沉默对高磷诱导的血管平滑肌细胞钙化的影响[J].中华医学杂志,2014,94(4):251-255. 被引量:7
-
2魏青,汤日宁,刘必成.慢性肾脏病患者高磷血症的危害性研究进展[J].中华实用诊断与治疗杂志,2014,28(11):1041-1043. 被引量:31
-
3于晓霞,刘红,常明.维持性血液透析患者腹主动脉钙化情况及其相关因素分析[J].国际医药卫生导报,2015,21(6):775-777.
二级引证文献38
-
1代红梅,龚孝春,王瑞宁.烟酰胺联合司维拉姆治疗血液透析高磷血症的临床研究[J].现代药物与临床,2018,33(12):3349-3353. 被引量:6
-
2李灿宇,马艳鸽,申爱荣.沉默COX-2基因对子宫腺肌病内膜间质细胞凋亡的影响[J].中国妇幼保健,2015,30(26):4548-4551. 被引量:1
-
3余毅,郭芳.CKD患者血管钙化与钙磷代谢紊乱[J].中国中西医结合肾病杂志,2015,16(10):847-850. 被引量:11
-
4丁红莲,汪裕伟,杨沿浪.维持性血液透析患者高磷血症的相关因素分析[J].安徽医药,2016,20(1):143-145. 被引量:18
-
5黄兰婷,陈友明,郑晓艳.维持性血液透析患者血磷水平及相关因素分析[J].社区医学杂志,2016,14(4):63-64.
-
6余毅,黄恬,霍苗苗,王琰.硫代硫酸钠减轻高磷诱导5/6肾切除大鼠的血管钙化[J].中华肾脏病杂志,2016,32(3):212-218. 被引量:7
-
7黄雅玲,王洪颖.健康教育对血液透析患者合并高磷血症的影响[J].中外医疗,2016,35(4):92-94. 被引量:3
-
8霍苗苗,余毅.DMP1、E11和Sclerostin在高磷诱导钙化的血管平滑肌细胞中的表达[J].中国中西医结合肾病杂志,2016,17(4):303-306. 被引量:3
-
9赵自霞,张蓓茹.司维拉姆治疗维持性血液透析患者高磷血症的研究进展[J].临床医药文献电子杂志,2016,3(14):2897-2898. 被引量:8
-
10肖雪,李瑛.维持性血液透析患者抑郁症状相关因素分析[J].中国现代医生,2016,54(14):75-77. 被引量:10
-
1刘翻利,马丽.慢性肾衰竭血管钙化机制研究进展[J].中国现代医生,2014,52(4):154-156. 被引量:6
-
2章斌,史伟.终末期肾病血管钙化机制[J].中华肾脏病杂志,2004,20(2):145-146. 被引量:7
-
3葛丽娜,方炜.终末期肾脏病血管钙化的机制[J].中国中西医结合肾病杂志,2011,12(8):746-747.
-
4刘倩.终末期肾病患者血管钙化机制进展[J].中国中西医结合肾病杂志,2015,16(7):657-658. 被引量:4
-
5柳诗意,张宁,刘世巍,孟祥飞.慢性肾脏病血管钙化机制研究进展及中医药研究概况[J].中国中西医结合肾病杂志,2015,16(4):352-356. 被引量:16
-
6张颖娟(综述),郑法雷(审校).慢性肾脏病血管钙化机制研究进展-抑制与促进血管钙化两类因子的重要作用[J].国际泌尿系统杂志,2008,28(4):505-509. 被引量:3
-
7郑法雷,章友康,陈香美,吴华.重视慢性肾病患者心血管病变的防治[J].北京医学,2011,33(2):81-81.
-
8黄湘华,陈劲松.肾移植受者心血管疾病的危险因素及其防治对策[J].肾脏病与透析肾移植杂志,2008,17(3):286-291.
-
9王政通,王莉.终末期肾脏病患者血管钙化危险因素及其调节因子[J].实用医院临床杂志,2011,8(5):168-172. 被引量:5
-
10江平,张荷,魏树林,王丽君,韩建妙.慢性肾功能衰竭患者心血管并发症及其危险因素临床观察[J].临床荟萃,2008,23(13):945-947. 被引量:5