诱导共刺激分子对Th17细胞发展的作用
摘要
Th17细胞是近年来被鉴定出的一类新型CD4阳性效应T细胞亚群,与传统的Th1、Th2细胞不同,该细胞具有独立的分化和发育调节机制。诱导共刺激分子(ICOS)是CD28家族的第3个成员,它在效应性T细胞上的表达具有正性共刺激作用。ICOS和Th17细胞都参与了肿瘤免疫,深入理解和认识ICOS对Th17细胞发展的作用,有助于设计新的有效的肿瘤治疗方案。
出处
《解剖学研究》
CAS
2013年第4期305-308,共4页
Anatomy Research
参考文献39
-
1Numasaki M, Watanabe M, Suzuki T, et al. IL-17 en- hances the net angiogenic activity and in vivo growth of hu- man non-small cell lung cancer in SCID mice through pro- moting CXCR-2-dependent angiogenesis. J Immunol, 2005, 175:6177-6189.
-
2Numasaki M, Fukushi J, Ono M, et al. Interleukin-17 pro- motes angiogenesis and tumor growth. Blood, 2003, 101: 2620-2627.
-
3Ye ZJ, Zhou Q, Gu , et al. Generation and differentia- tion of IL-17- producing CD4 cells in malignant pleural ef- fusion. J Immunol, 2010,185(10) : 6348-6354.
-
4Carmeliet P, Jain RK. Angiogenesis in cancer and other diseases. Nature, 2000,407 : 249-257.
-
5Kryczek I, Lange A, Mottram P, et al. CXCL12 and vascu- lar endothelial growth factor synergistically induce neoangio- genesis in human ovarian cancers. Cancer Res, 2005,65: 465-472.
-
6周帆,陈文荣,张黎,郑璇杏,潘德顺.Graves病小鼠模型IL-10水平与Th17细胞功能的检测和意义[J].解剖学研究,2012,34(6):424-427. 被引量：1
-
7Kryczek I, Banerjee M, Cheng P, et al. Phenotype, distri- bution, generation, and functional and clinical relevance of Thl7 cells in the human tumor environments. Blood, 2009, 114(6):1141-1149.
-
8Hue S, Ahem P, Buonocore S, et al. Interleukin-23 drives innate and T cell-mediated intestinal inflammation. J Exp Med, 2006,203 : 2473-2483.
-
9Overwijk WW, De Visser KE, Tirion FH, et al. Immuno- logical and antitumor effects of IL-23 as a cancer vaccine adjuvant. J Immunol , 2006, 76:5213-5222.
-
10Hu J, Yuan X, Belladonna ML, et al. Induction of potent antitumor immunity by intratumoral injection of interleukin 23-transduced dendritic ceils. Cancer Res, 2006,66:8887- 8896.
二级参考文献12
-
1Zhu S, Qian Y. IL-17/IL-17 receptor system in autoimmune disease: mechanisms and therapeutic potential. Clin Sci (Lond), 2012,122(11) :487-511.
-
2NicteFV, Manuel AP, Ignacio B, et al. Increased circulating pro-inflammatory cytokines and Th17 lymphocytes in Hashimoto's thyroiditis. J Clin Endocrinol & Metabolism, 2010,95 (2) : 953-962.
-
3Ueki I, Abiru N, Kawagoe K, et al. Interleukin 10 deficiency attenuates induction of anti-TSH receptor antibodies and hyperthyroidism in a mouse Graves' model. Journal of Endocrinology, 2011, 209( 1 ) : 353-357.
-
4Saitoh O, Mizutori Y, Takamura N, et al. Adenovirus- mediated gene delivery of interleukin-10, but not transforming growth factor 6, ameliorates the induction of Graves'hyperthyroidism in BALB/c mice. Clinical and Experimental Immunology, 2005,141 (2) : 405-411.
-
5Wilke CM, Wang L, Wei S, et al. Endogenous interleukin-10 constrains Th17 cells in patients with inflammatory bowel disease. Journal of Translational Medicine, 2011,9(1) :217-230.
-
6Inaba H, Pan D, Shin Y, et al. Immune response of mice transgenic for human histocompatibity leukocyte antigen- DR to human thyeotopin receptor-extracellular domain. Thyroid, 2009,19( 11 ) : 1271-1280.
-
7Kim SE, Yoon JS, Kim KH, et al. Increased serum interleukin-17 in Graves' ophthalmopathy. Graefes Arch Clin Exp Ophthalmol, 2012 Jul 1. [Epub ahead of print].
-
8Asadullah K, Sterry W, Volk HD. Interleukin-10 therapyreview of a new approach. Pharmacological Reviews, 2003,55 ( 1 ) : 241-269.
-
9Batteux F, Trebeden H, Charreire J , et al. Curative treatment of experimental autoimmune thyroiditis by in vivo administration of plasmid DNA coding for interleukin- 10. European Journal of Immunology, 1999,29 (2) : 958- 963.
-
10Zhang GX, Xiao BG, Yu LY, et al. Interleukin 10 aggravates experimental autoimmune myasthenia gravis throughinducing Th2 and B cell responses to AChR. Journal of Neuroimmunology, 2001,113 (1) : 10-18.
-
1丁艳,蒙秉新.诱导共刺激分子与系统性红斑狼疮的研究进展[J].中国麻风皮肤病杂志,2009,25(10):758-760.
-
2赵斌,许爱娥.诱导共刺激分子研究新进展[J].中国中西医结合皮肤性病学杂志,2006,5(2):123-124. 被引量：1
-
3迟铖,陈剑.嵌合抗原受体T细胞在肿瘤免疫治疗中的研究进展[J].齐鲁医学杂志,2016,31(5):617-618.
-
4刘耀阳,沈茜.ICOS共刺激途径对CD4^＋调节性T细胞的影响[J].国际免疫学杂志,2009,32(2):113-117.
-
5许雪青.ICOS:一种重要的新型诱导共刺激分子[J].第三军医大学学报,2003,25(4):351-354. 被引量：2
-
6周建华,苏燎原,童建,薛莲.影响淋巴细胞共刺激作用的体外实验研究[J].苏州医学院学报,2000,20(7):614-616.
-
7周东明,徐燕霞,袁育青,陈萍,孙谕,傅晋翔.滤泡辅助性T细胞和相关分子在淋系恶性疾病中的变化及其意义[J].白血病．淋巴瘤,2016,25(3):157-162.
-
8吴剑卿,孙芸,余多慰,殷凯生.ICOS-ICOSL共刺激通路及其功能的研究进展[J].国外医学（生理病理科学与临床分册）,2003,23(5):475-478. 被引量：2
-
9王顺友,孙雨,马宝骊.抗 CD3 、 CD28 单抗对人 T 淋巴细胞共刺激作用的影响因素[J].上海免疫学杂志,1999,19(4):229-231. 被引量：4
-
10钟维敏,蒋益.消化性溃疡幽门螺杆菌感染与Toll样受体4基因多态性的相关性研究[J].浙江临床医学,2008,10(9):1184-1185. 被引量：1
