泮托拉唑预防机械通气患者并发应激性溃疡的疗效研究

Effect of pantoprazole preventing stress ulcer in the mechanical ventilation patients

目的观察泮托拉唑在预防机械通气患者并发应激性溃疡中的临床疗效。方法 60例因严重肺部感染或慢性阻塞性肺病急性发作导致呼吸衰竭而行机械通气治疗的患者,随机分成两组,除基础治疗外,观察组(n=30)给予泮托拉唑40mg每日1次静脉滴注,对照组(n=30)不给予抑酸药物,观察两组患者上消化道出血的发生情况,并对发生上消化道出血患者行急诊胃镜检查,明确应激性溃疡诊断。同时记录两组患者的住院天数。结果观察组应激性溃疡的发生率(3.3%,1/30)明显低于对照组(20.0%,6/30)(P=0.044)。观察组平均住院时间(17.5±4.7)d也明显短于对照组(21.3±6.0)d(P=0.008)。结论泮托拉唑可有效预防因呼吸衰竭而接受机械通气治疗的患者中应激性溃疡的发生,并缩短住院时间。

Objective To demonstrate the effect of pantoprazole preventing stress ulcer in the mechanical ventilation patients. Methods 60 mechanical ventilated patients with respiratory failure due to severe pulmonary infection or chro- nic obstructive pulmanary disease were randomly divided into two groups. Besides same basic therapy, the observation group （n = 30） were treated with pantoprazole （40 mg qd ivgtt）, while the control group （n = 30） were not treated with gastric acid inhibitor. Upper gastrointestinal bleeding occurred during treatment was surveyed, and if occurred, emer- gency gastroscopy was performed. The stress ulcer was diagnosed by gastroscopy. The hospital days were also recorded. Results The incidence of stress ulcer was significantly lower in the observation group than that in the control group （3.3 % , 1/30 vs 20.0% , 6/30, P = 0. 044）. The hospital days was also significantly less in the observation group than that in the control group （17.5 d±4.7 d vs 21.3 d±6.0 d, P =0.008）. Conclusion Pantoprazole could prevent stress ulcer in the mechanical ventilation patients with respiratory failure effectively, and shorten the hospital days.