实时组织超声弹性成像在胆汁性肝硬化患者中的应用价值

Dignostic value of the elastography in real time for the patients with biliary cirrhosis

目的探讨实时组织超声弹性成像(RTE)在胆汁性肝硬化患者中的诊断价值。方法以30例胆汁性肝硬化患者(胆汁性肝硬化组)及15例健康志愿者(正常组)为研究对象,利用RTE定量分析两组肝脏弹性的11个变量,包括应变均值、标准偏差、蓝色领域、复杂度、偏度、峰度、对比度、均等度、杂乱度、一致性及相关性,通过软件处理,得出弹性值LF Index,以肝组织取活检的病理为依据,通过统计学方法,探讨它们的相关性。结果除偏度、相关性两个变量,胆汁余变量与正常组比较差异均有统计学意义(P<0.05)。LF Index与肝穿病理结果的相关系数R值为0.714,双侧Pearson检验P<0.001。正常组与胆汁性肝硬化组LF Index分别为1.88±0.45、3.60±0.94,差异有统计学意义(P<0.05)。结论 RTE可以成为判断胆汁性肝硬化患者的一种无创性检查方法。

Objective To investigate the diagnostic value of real-time tissue elastography in patients with biliary cirrhosis. Methods Thirty patients with biliary cirrhosis and 15 healthy volunteers were enrolled in this study. Data of 11 parameters such as the strain mean, standard deviation, blue areas, complexity, kurtosis, skewness, contrast, equalization of degrees, clutter degrees, and consistency, correlation were collected, and analyzed with software processing. The elasticity LF Index was calculated from the 11 parameters. All parameters and LF Index were compared to the result of liver biopsy, and the relevance was analyzed through statistical methods. Results Except for the skewness, and correlation, the difference of all parameters between the control group and the biliary cirrocis group was statistically significant （P〈0.05）. The LF Index and the liver biopsy pathologic results was tightly correlated （R value=0.714, bilateral Pearson test P〈0.001 ）. LF lndex in the control group and the biliary cirrhosis group was significantly different （P〈0.05）. Conclusion The real time elastography can be used to identify biliary cirrhosis noninvasivly.