OMOM胶囊内镜在无症状人群体检中的应用

The application of capsule endoscopy in medical examination of asymptomatic population

目的探讨OMOM胶囊内镜在无症状人群体检中应用价值。方法受检者为2005年8月-2010年3月到北京军区总医院消化内科进行胶囊内镜检查的无症状体检人群,受检者按就诊的时间顺序随机分为研究组(A组)、对照组(B组)、自身对照组(C组)。A组受检者按一定体位进行胶囊内镜检查,送服胶囊后立即依次平卧位3 min,左侧卧位3 min,右侧卧位3 min,半卧位3min,观察食管黏膜情况,再观察胃依次左侧卧位10 min,平卧位10 min,右侧卧位10 min,站立位10 min,随后可自由活动,直至胶囊内镜排出体外。B组受检者按常规要求进行胶囊内镜检查。C组受检者进行胶囊内镜检查后即安排胃镜和结肠镜检查。结果 A组和B组胶囊内镜食管运行平均时间和胃排空平均时间差异均有统计学意义(P<0.05);但A组和B组胶囊内镜排出平均时间差异无统计学意义(P>0.05)。A组和C组胶囊内镜食管运行平均时间和排出平均时间差异均有统计学意义(P<0.05);但A组和C组胶囊内镜胃排空平均时间差异无统计学意义(P>0.05)。90例A组受检者中检出消化道病变者28例,检出率31.11%;160例B组受检者中检出消化道病变者42例,检出率26.25%;110例C组受检者中检出消化道病变者43例,检出率39.09%。A组和B组食管病变检出率比较差异具有统计学意义(P<0.05)。结论胶囊内镜在特定体位下可以提高食管及胃病变检出率。胶囊内镜检查可以指导胃镜及结肠镜检查能更有效提高消化道疾病检出率,用于无症状人群体检无疑是一种安全、无创、无痛苦的消化道检查方法。

Objective To investigate the role of capsule endoscopy in medical examination of asymptomatic population. Methods From Aug. 2005 to Mar. 2010, 360 individuals were randomized according to visit order and divided into study group （A） and control groups （B and C）. The subjects in group A were taken capsule endoscopy in specific body position, while subjects in group B were taken capsule endoscopy secundum artem and group C were taken esopha- gogastroduodenoscopy and colonoscopy just after capsule endoscopy. Results There were significant differences in the average time of esophageal operation and the average time of gastric emptying between group A and group B （P 〈 0.05） , but no difference in the average excreted time （P 〉 0.05 ）. There were significant differences in the average time of esophageal operation and the average excreted time between group A and group C （P 〈 0.05） , but no difference in the average time of gastric emptying （P 〉0.05）. The detection rate in group A was 31. 11% （28/90）, while 26.25% （42/160） in group B and 39.09% （43/110） in group C. The difference of detection rate of esophageal lesions was significant between group A and group B. Conclusion Capsule endoscopy is effective and safe in medical examination of asymptomatie population.