鼻用糖皮质激素治疗儿童上气道咳嗽综合征疗效观察

Therapeutic effect of intranasal corticosteroid for upper airway cough syndrome in children

目的分析丙酸氟替卡松鼻喷剂在儿童上气道咳嗽综合征治疗中的疗效。方法 121例诊断为上气道咳嗽综合征(upper airway cough syndrome,UACS)的患儿随机分为治疗组(63例)和对照组(58例),所有患者根据原发病因采用抗炎、抗过敏等对症治疗,同时避免接触变应原。治疗组加用丙酸氟替卡松鼻喷剂喷鼻,对照组伴鼻塞患者加用呋麻滴鼻液。疗程结束后采用视觉模拟量表判断咳嗽缓解情况。结果随访4周,两组患者慢性咳嗽、鼻后滴流等症状均有不同程度改善,治疗组有效率(93.65%)明显高于对照组(74.14%),差异具有统计学意义(P<0.05)。结论鼻用糖皮质激素治疗以慢性咳嗽为主要表现的儿童上气道咳嗽综合征安全有效,值得临床推广应用。

Objective To analyze the therapeutic effect of fluticasone propionate nasal spray for upper airway cough syndrome （UACS） in children. Methods 121 pediatric patients with UACS were randomly divided into two groups, i.e. therapeutic group （n = 63 ） and control group （n = 58 ）. The primary diseases in both groups were treated with homologous therapeutic measures. The patients of therapeutic group were given fluticasone propionate while those of the control group were given nose drop of nitrofural and ephedrine hydroehloride. After continuous treatment for 4 weeks, visual analog scale （ VAS ） was adopted to evaluate the improvement of cough. Results All patients were followed up for 4 weeks, the symptoms including chronic cough, postnasal drip got relieved to different degree in all cases. The effective rate of therapeutic group was higher than that of the control group, and the difference was statistically significant （P 〈 0.05 . Conclusions Intranasal eortieosteroid is safe and effective for the treatment of UACS in pediatric patients.