维持性血液透析患者他汀类调脂治疗

Advancement in statin regimens in patients undergoing maintenance hemodialysis

脂代谢紊乱是诱发心脑血管事件的重要危险因素,已有大量研究证实,应用他汀类药物调脂治疗对心脑血管的保护作用。维持性血液透析(MHD)患者常伴严重的脂代谢异常,心脑血管疾病亦是MHD患者的主要死亡原因。因此,他汀类药物能否降低MHD患者心脑血管事件的发生率及相关死亡率已成为近来研究热点之一。本文对他汀类药物应用于MHD患者的临床研究进展作一综述。

The patients with maintenance hemodialysis （MHD） are associated with accelerated atherosclerosis and increased morbidity and mortality frown cardiovascular disease.MHD patients are characterized by a complex plasma dyslipoproteinemic profile.Statin therapy has been proved to reduce the incidence of cardiovascular events and mortality in diverse patient populations at increased risk.There has been concern about the efficacy and safety of statin in MHD patients.This review will focus on the relevant progresses of statin therapy in patients undergoing MHD treatment.