腹膜保护——透析液以外的影响因素

Protecting the peritoneal membrane: factors beyond peritoneal dialysis solutions

腹膜透析(PD)是终末期肾病的主要肾脏替代疗法之一。尽管新型透析液具有良好的生物相容性,但其腹膜的保护作用尚未被临床证实,究其原因在于PD患者存在除PD液以外,同样能影响腹膜结构的其他因素。本文主要综述除PD液影响腹膜结构和功能危险因素,为腹膜保护找到新的方法。

Peritoneal dialysis （PD） is one of the main renal replacement therapy for end-stage renal disease.Although newer solutions have excellent biocompatibility,their clinical benefit on the preservation of peritoneal membrane integrity remains unproven so far.The difficulties in showing a benefit of the newer,more biocompatible solutions in the clinical setting can be explained by the fact that other factors also affect the properties of the peritoneal membrane.This review focuses on factors that potentially influence the integrity of the peritoneal membrane,other than those associated with the peritoneal dialysis fluid itself.And attention should be paid to them in order to find new approaches to protect the peritoneal membrane.