双特异性磷酸酶1在子宫内膜样腺癌组织中表达及与预后的关系

Relationship between the expression of dual specificity phosphatase-1 and the prognosis of endometrioid adenocarcinoma

目的 探讨双特异性磷酸酶1（DUSP1）在子宫内膜样腺癌组织中的表达与预后的关系.方法 采用免疫组织化学方法检测DUSP1在81例手术切除的子宫内膜样腺癌组织标本中的表达,并分析DUSP1与临床病理特征及预后的关系.结果 81例中59例（72.84％）阳性表达,22例阴性表达.DUSP1与手术分期、病理分级、肌层浸润、ER及PR相关（P＜0.05）,与淋巴结转移无关.Kaplan-Meier生存分析显示DUSP1表达阳性组与阴性组5年无瘤生存率分别为98.2％和76.0％（P＜0.05）.COX回归分析显示DUSP1与PR为子宫内膜样腺癌预后的独立危险因素,DUSP1阴性与阳性表达的相对危险度为21.2.Spearman相关分析显示DUSP1与PR的表达呈正相关（r=0.256,P＜0.05）.结论 DUSP1表达下降可作为子宫内膜癌预后不良的潜在标志物.

Objective To clarify the relationship between the expression of dual specificity phosphatase-1 （ DUSP1 ） and the prognosis of endometrioid adenocareinoma. Methods The expression of DUSP1 was determined by immunohistoehemical staining in specimens from 81 patients with endometrial carcinoma undergoing surgical resection. The relationship between DUSP1 expression, clinicopathological factors and prognosis were further evaluated. Results In 81 endometrioid carcinoma samples, 59 （72. 84% ） cases were positive while 22 negative. Except for lymph node metastasis, the expression of DUSP1 was correlated with FIGO stage, tumor grade, myometrial invasion and the expressions of estrogen receptor （ER） and progesterone receptor （PR） （P 〈 0. 05 ）. Kaplan-Meier analysis showed that patients with a positive DUSP1 expression had significantly prolonged 5-year disease-free survival rates of 98.2% and 76. 0% respectively （ P 〈 0. 05 ）. And COX regression analysis revealed that the expressions of DUSP1 and PR were independent prognostic indicators of endometrioid carcinoma, the HR （ hazard ratio） of DUSP1 negative expression was 21.2. Spearman analysis further showed that the expression of DUSP1 was positively correlated with PR （ r = 0. 256, P 〈 0. 05 ）. Conclusion DUSP1 may be a potential negative prognostic indicator for endometrioid adenocarcinoma.