LOX-1与动脉粥样硬化被引量：1

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摘要 LOX—1是氧化型低密度脂蛋白（oxidizedlowdensitylipoprotein，OX—LDL）、细菌、病毒、LPS等多种内源性和外源性致病因子的受体，是目前关于动脉粥样硬化疾病研究最热门的蛋白．在动脉粥样硬化病程中，LOX-1在脂质堆积，内皮功能紊乱，斑块形成和破裂以及在此过程中的一系列炎性反应中都存在表达，且在多种细胞如血管内皮细胞，血管平滑肌细胞、巨噬细胞等多种细胞都有表达，是介导OX—LDL结合、内吞、降解的特异性受体，是与动脉粥样硬化治疗、预防和康复密切相关的因子，LOX—1抑制剂已经成为抗动脉粥样硬化药物设计的新方向．本文就LOX-1与动脉粥样硬化的研究做系统的综述．

作者沈志强

机构地区药学院暨云南省天然药物药理重点实验室

出处《昆明医科大学学报》 CAS 2013年第8期1-4,27,共5页 Journal of Kunming Medical University

关键词动脉粥样硬化疾病 LOX-1 氧化型低密度脂蛋白血管平滑肌细胞抗动脉粥样硬化特异性受体内皮功能紊乱血管内皮细胞

分类号 R543.5 [医药卫生—心血管疾病]

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参考文献32

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