摘要
目的探讨外周血浆NT-proBNP水平与冠状动脉病变严重程度的相关性.方法急性冠脉综合征患者83例,稳定性心绞痛62例,正常对照40例.采用酶联免疫吸附法检测血浆NT-proBNP水平,将急性冠脉综合征患者与稳定性心绞痛病人的血浆NT-proBNP水平进行分析,同时根据冠脉造影结果将冠心病患者分为单支病变组、双支病变组及三支病变组进行分析,将冠状动脉病变程度积分与血清NT-proBNP水平进行相关性分析.结果 (1)ACS组血清NT-proBNP水平明显高于SA组和正常人(P<0.01);(2)三支病变组血清NT-proBNP水平明显高于双支病变组和单支病变组,而双支病变组又高于单支病变组;(3)血清NT-proBNP水平与冠状动脉病变程度积分进行相关性分析,结果呈正相关,相关系数rs=0.796,P<0.01.结论血清NT-proBNP水平与冠状动脉病变严重程度密切相关.
Objective To investigate the correlation between plasma NT-proBNP and the severity of coronary artery disease. Methods One hundred and eighty five subjects were divided into three groups：83 patients in acute coronary syndromes group, 62 patients in stable angina pectoris group and 40 healthy subjects in normal group. The plasma NT-proBNP concentrations were measured by enzyme-linked immunosorbent assay （ELISA） . The plasma NT-proBNP levels of acute coronary syndrome patients and stable angina patients were analyzed. Furthermore, the coronary syndrome patients were divided into three groups according to the result of angiography： single vessel group, dual-vessel group and multiple-vessel group. The relationship of plasma NT-proBNP levels with the severity of coronary artery disease was analyzed. Results （1） In the group of acute coronary syndromes, the plasma NT-proBNP concentrations were obviously higher than the stable angina pectoris group and normal group （P〈 0.01） （2） In the groups of coronary heart disease, the plasma NT-proBNP concentrations of the muhiple-vesel group were obviously higher than the single vessel group and the dual-vessel group （P 〈0.01） . The plasma NT-proBNP concentrations of dual-vessel group were obviously higher than the single vessel group （P〈0.01） （3） The plasma NT-proBNP levels and the severity of coronary lesions were positively correlated （rs =-0.796, P〈0.01） . Conclusion The plasma NT-proBNP levels is closely related to the severity of coronary artery disease.
出处
《昆明医科大学学报》
CAS
2013年第8期81-83,共3页
Journal of Kunming Medical University
基金
江西省吉安市科技局资助项目[吉安科计字(2012)32号-44]
