骨骼肌卫星细胞对肉品质的影响及其分化调控

The influence of satellite cells on meat quality and its differential regulation

骨骼肌卫星细胞是一种肌源性干细胞,在骨骼肌的生长、发育及肌肉损伤修复中有着至关重要的作用。肌卫星细胞通过增殖、分化融合肌纤维形成新的肌核从而导致骨骼肌纤维的肥大以及骨骼肌纤维类型的相互转化,进而影响肉品质的形成。文章从肌纤维的发育与肉品质形成、卫星细胞分化与肌纤维特征的相关性等方面,对卫星细胞的Notch等经典遗传信号通路和miRNA等表观遗传调控及其对肉品质的影响进行了综述。

Satellite cell is a kind of myogenic stem cells, which plays an important role in muscle development and injury repair. Through proliferation, differentiation and fusion of muscle fiber can satellite cells make new myonuclear, leading to the hypertrophy of skeletal muscle and fiber type transformation, and this would further affect the meat quality. Here, we review the relationship between muscle fiber development and meat quality attributes as well as the influence of the satellite cell differentiation on muscle fiber character. Besides, we also summarize the classical signaling pathway （i.e., Notch etc.） and influence of epigenetic regulation （i.e. miRNA） on muscle quality.