miRNA在调控皮肤和毛囊发育中的作用

miRNA in regulation of skin and hair follicle development

表皮发生和毛囊的周期性再生涉及一系列基因的激活和沉默。近年来的研究表明,miRNA的表达谱在表皮和毛囊组织中存在组织特异性,在毛囊周期性发育中存在阶段特异性。大量miRNA参与表皮和毛囊的发生,色素的沉着以及毛囊的周期性发育过程,不同类型细胞中的miRNA通过与信号通路和调控因子相互作用形成了一个全方位、多层次的网络调控系统。文章综述了miRNA调控表皮内稳态和毛囊周期性发育的一些研究进展,旨在丰富miRNA参与的基因调控网路的研究,进而为人工调控miRNA进行疾病治疗和分子育种提供帮助。

Epidermal development and cyclic hair follicle regeneration are governed by well-balanced programs of gene activation and silencing. Recent researches demonstrated that the expression profiles of miRNA showed tissue-specific expression patterns in the epidermis and hair follicles and stage-specific in cyclical development of hair follicles. Furthermore, a large number of miRNAs are involved in the development of epidermis and hair follicles, pigmentation, and the cyclical development of hair follicles, miRNAs in different cell types formed a comprehensive, multi-level network system through interaction with signal pathway and regulation factors. This review summarizes the available progress on how miRNAs are involved in the control of epidermal homeostasis and hair follicle development to enrich the research of gene regulatory networks and contribute to disease treatment and molecular breeding.