超声造影在兔肝纤维化实质灌注的定量评估

Quantitative assessment of liver parenchymal perfusion in rabbit liver fibrosis model by contrast-enhanced ultrasonography

目的:采用实时灰阶超声造影定量分析纤维化兔肝的实质灌注情况。方法:对30例经硫代乙酰胺诱导的兔肝纤维化模型行超声造影定量分析,并将结果与病理对照。结果:造影灌注峰值强度随着兔肝纤维化程度(Sa～Sd)加重而逐渐减低,除Sb组与Sc组间峰值强度差异外,其余各组间差异均有统计学意义(P<0.05);而Sa组与Sb组及Sc组间的对比剂到达时间差异有统计学意义(P<0.05),且3组呈逐渐减低趋势;Sd组的达峰时间明显高于其余各组,且其与Sa组及Sc组间差异有统计学意义(P<0.05)。结论:通过实时灰阶超声造影可观察并评估肝纤维化程度。

Objective： Using real time gray scale contrast enhanced ultrasonograpy（CEUS）to assess quantitatively the parenchymal perfusion of rabbit liver fibrosis model. Methods- Contrast-enhanced ultrasound quantitative assay was performed in 30 thioacetamide （TAA）-induced rabbit liver fibrosis model, and the results were compared with pathology examination. Results： The peak intensity （PI） decreased gradually with the increase of liver fibrosis Sa-Sd）. With the exception between group Sb and Sc, the peak intensity between these groups differed significantly （P〈0.05）. The contrast agent arrival time （AT） differed significantly （P〈0.05） between group Sa, Sb and Sc with a gradually decreasing trend. The time to peak intensity （TIP） of Sd group was significantly higher than the other groups. Conclusions： Degree of liver fibrosis could be evaluated by real time gray scale contrast-enhanced ultrasonography.