505例宫颈癌临床病例分析

The clinical analysis of 505cases of cervical cancer

目的本研究探讨宫颈癌患者预后相关危险因素,以指导其处理及随访。方法收集北京大学深圳医院近10年间宫颈癌患者505例,研究其临床病理特点与预后的相关因素,采用SPSS 19.0软件分析,P〈0.05为差异有统计学意义。结果①本研究患者发病年龄高峰为35-45岁,呈单峰,3年、5年总体生存率分别为94%、93%;②多因素分析,临床分期、组织分化程度、以铂类为基础的同步化放疗是影响宫颈癌预后的独立危险因素（P〈0.05）。结论本研究患者发病年龄高峰为35-45岁,呈单峰。3年、5年总体生存率高于文献报道。临床分期、组织分化程度、以铂类为基础的同步化放疗是影响宫颈癌预后的独立危险因素。

Objective To evaluate the related risk factors that affect the prognosis of cervical cancer.Methods The clinical data of 505cases of cervical cancer patients who treated in the Department of Gynecologic Oncology of Peking University Shenzhen Hospital in the past 10years were analyzed retrospectively.The clinic pathologic clinicopathologic features and risk factors that related to the prognosis of cervical cancer were analyzed by statistical software SPSS 19.0.A statistically significant difference was indicated by P0.05.Results ① The peak age of onset focus on 35-45years old which showed a single-peak,the 3-year and 5-year survival rates of all patients were 94% and 93%.② The multivariate regression analysis indicated that clinical stage,histology differentiated grades,platinum-based chemoradiotherapy were independent prognosis factors for cervical cancer patients（P0.05）.Conclusions The peak age of cervical cancer patients in this study focus on 35-45years old which showed a single-peak.The 3-year and 5-year survivals were higher than that reported in the literature.Histology differentiated grades,platinum-based chemoradiotherapy were independent prognosis factors for cervical cancer patients.