假丝酵母黏附相关糖基磷脂酰肌醇锚定细胞壁蛋白的研究进展

Study of adhesion-related glycosylphosphatidylinositol-anchored cell wall proteins in Candida species

假丝酵母(俗称念珠菌)是人类重要的条件致病性真菌,可导致人体浅表组织感染,甚至入侵血流引起念珠菌血症和播散性念珠菌病。黏附是念珠菌机会性感染的第1步,该过程受黏附蛋白的精确调控。糖基磷脂酰肌醇锚定细胞壁蛋白(GPI-CWP)家族中有许多成员参与调控念珠菌的黏附。本文就几种重要的念珠菌黏附相关GPI-CWP:凝集样序列(Als)、菌丝壁蛋白1(Hwp1)、上皮细胞黏附素(Epa)、聚苯乙烯黏附增强蛋白1(Eap1)等的致病机制展开综述。

Candida species are the most prevalent opportunistic fungal pathogens in human causing su and serious systemic infections. The infection process can be divided into three stages： adhesion, invasion, and host cell damage. Adhesion is the first stage of the invasive Candida infection process and is precisely controlled by adhesins. Many of these adhesion-related proteins are members of glycosylphosphatidylinositol anchored cell wall protein （GPI-CWP） family. This review is intended to summarize adhesins mediated by GPI-CWP： agglutinin-like sequence （Als）, hyphal wall protein 1 （Hwpl）, epithelial adhesin （Epa）, and enhanced adherence to polystyrene 1 （Eapl）.