头痛灵胶囊对脑血管及血液粘度的影响

Effect of Toutongling Capsule on Cerebral Vessels and Blood Viscosity

由冰片、石菖蒲、川芎、细辛、白芍等药组成的头痛灵胶囊是在古方基础上加减 ,经现代工艺制成的纯中药制剂 ,经临床对照研究证明对血管性、紧张性、外伤性头痛均有较好疗效。为进一步探讨其药理作用机制 ,观察了头痛灵胶囊粉对犬脑血管和血液粘度的影响 ,结果表明 :头痛灵胶囊粉可明显降低实验犬的脑血管阻力 ,增加脑血流量 ,并呈良好的量效关系 ,与复方羊角冲剂相比 ,二者对血液粘度的影响基本相似 ,但前者扩张脑血管 ,增加脑血流量的作用较强 ,而二者对血压。

Toutongling Capsule is a Chinese herbal preparation developing from an ancient formula processed by modern technology. Previous clinical studies have shown that Toutongling Capsule exerts a good effect on vascular headache, tonic headache and traumatic headache. To further explore its pharmacological mechanism, the effect of Toutongling Capsule on cerebral vessels and blood viscosity in experimental dogs was observed. The results showed that Toutongling Capsule can decrease cerebral vascular resistance obviously and increase cerebral blood flow, with a good dose-effect relationship. As compared with Yangjiao Granule, Toutongling Capsule possesses a similar effect on blood viscosity but stronger effect on dilatation of cerebral vessels and increase of cerebral blood flow. Both Toutongling Capsule and Yangjiao Granule have no effect on blood pressure and ECG.